Table 3

Mediators of inflammation and articular damage up-regulated in DA synovium and down-regulation in DA.F344(Cia5a)
Gene Symbol Gene Name Entrez Gene ID Fold DA/Cia5a p-value*
Cytokines and chemokines
Il1b interleukin 1 beta 24494 5.17 0.002
Il18 interleukin 18 29197 3.91 0.0002
Ltb lymphotoxin beta 361795 3.77 0.0002
Mif macrophage migration inhibitory factor 81683 2.37 0.0002
Aif1 allograft inflammatory factor 1 29427 2.48 0.0001
Ccl2 chemokine (C-C motif) ligand 2 24770 3.95 0.01
Ccl7 chemokine (C-C motif) ligand 7 287561 7.90 0.002
Cxcl1 chemokine (C-X-C motif) ligand 1 81503 10.88 0.0004
Cxcl13 chemokine (C-X-C motif) ligand 13 498335 7.53 0.000004
Proteases
Mmp3 matrix metallopeptidase 3 171045 23.94 0.0001
Mmp9 matrix metallopeptidase 9 81687 32.79 0.000000001
Mmp14 matrix metallopeptidase 14 81707 4.46 0.000000004
Mmp19 matrix metallopeptidase 19 304608 5.63 0.0000003
Ctsc cathepsin C 25423 2.64 0.00007
Ctsd cathepsin D 171293 1.90 0.000002
Ctse cathepsin E 25424 2.03 0.0002
Ctsk cathepsin K 29175 3.20 0.0000003
Ctss cathepsin S 50654 1.68 0.002
Extra-cellular matix
Cthrc1 collagen triple helix repeat containing 1 282836 17.93 0.000000003
Col12a1 collagen, type XII, alpha 1 25683 16.25 0.00000008
Emilin1 elastin microfibril interfacer 1 298845 13.55 0.000002
Adhesion molecules
Itga5 integrin alpha 5 (fibronectin receptor alpha) 315346 3.47 0.00000001
Itgam integrin alpha M 25021 3.58 0.0001
Itgav integrin alpha V 296456 1.61 0.0004
Itgb2 integrin beta 2 309684 3.44 0.0001
Itgb7 integrin, beta 7 25713 3.86 0.002
Cd44 Cd44 molecule 25406 1.83 0.005
Cdh11 cadherin 11 84407 1.87 0.003
Toll-like receptors and regulators of their activity
Cd14 CD14 60350 2.13 0.001
Irak4 interleukin-1 receptor-associated kinase 4 300177 1.65 0.0004
Lpb lipopolysaccharide binding protein 29469 4.36 0.0003
Myd88 myeloid differentiation primary response gene 88 301059 1.59 0.002
Pycard PYD and CARD domain containing 282817 1.95 0.0004
Tlr2 toll-like receptor 2 310553 4.36 0.000
Tlr6 toll-like receptor 6 305353 1.76 0.001
Prostaglandin and leukotriene synthesis
Ptgs2 prostaglandin-endoperoxide synthase 2 29527 9.73 0.0006
Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) 24653 2.04 0.0004

*t-test.

Brenner and Gulko

Brenner and Gulko BMC Genomics 2012 13:710   doi:10.1186/1471-2164-13-710

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