Table 3

Biological processes associated with the identified overlapping genetic regulators of neurodegeneration.

Biological process

Genes


Heat shock transcription factor

hsf-1

Molecular chaperones

hsp-1, dnj-13, cct-4, cct-5

Ubiquitin related

chn-1, ubc-8, let-70, cdc-48.1

Histone deacetylases

sir2.1, had-1, sin-3

Signalling/chaperone

fft-2/par-5

Transcriptional cofactor/regulator

ctbp-1, let-19, mdt-17, uaf-2

Nucleopore/nuclear export

npp-18, xpo-1

Vesicular transport

rab-1, sft-4, tbc-20, ykt-6, dhc-1

Endocytosis

unc-11, unc-26

Transport ATPase

catp-6, pmr-1, vha-15

Protein phosphorylation

kin-18, H18N13.2

Other cellular processes

bli-3, phi-49, F59F4.1


Chen and Burgoyne BMC Genomics 2012 13:71   doi:10.1186/1471-2164-13-71

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