Table 2

Overlapping genetic regulators of neurodegeneration with orthologues in C.elegans

Sequence Name

Gene name

Description

Organism

Disease model

Expression in neurons


Y53C10A.12

hsf-1

Heat-shock transcription factor

worm

Aβ, P, S, SOD, T

yes

F26D10.3

hsp-1

HSP70 protein family

fly, worm

P, T, S

yes

F54D5.8

dnj-13

Molecular chaperone (DnaJ)

fly

P, T

?

K01C8.10

cct-4

Chaperone containing TCP-1

worm

P, SOD

yes

C07G2.3

cct-5

Chaperone containing TCP-1

worm

P, SOD

?

T09B4.10

chn-1

C-term of HSP-70 interacting protein (E3 ubiquitin ligase)

fly, worm

P, T

yes

Y94H6A.6

ubc-8

Ubiquitin conjugating enzyme

fly, yeast

P, S

?

M7.1

let-70

E2 Ubiquitin conjugating enzyme

fly

P

yes

C06A1.1

cdc-48.1

AAA ATPase, functions as a ubiquitin-related chaperone

worm

P

Yes

F52D10.3, M117.2

ftt-2, par-5

14-3-3 family

fly

P

yes

C39F7.4

rab-1

Small Ras-like GTPase Rab1

fly, yeast, worm

P, S

yes

B0361.10

ykt-6

SNARE protein YKT6

yeast

S

?

C54H2.5

sft-4

SURF-4 related to cargo transport protein ERV29

worm, yeast

S

yes

Y54E2A.12

tbc-20

Predicted GTPase activator protein

yeast

S

?

R11A8.4

sir-2.1

NAD-dependent histone deacetylase

fly, worm

P, S

Yes

C53A5.3

hda-1

Histone deacetylase 1

fly, worm

P, S

No?

F02E9.4

sin-3

SIN3 family of histone deacetylase subunits

fly

P, S

yes

F59F4.1

-

Acyl-CoA oxidase

fly, yeast, worm

P, S, T

?

ZK256.1a

pmr-1

Golgi P-type ATPase Ca2+ -pump

yeast

S

yes

W08D2.5,

catp-6

Predicted lysosomal P-type ATPase

worm, yeast

S

?

Y43F4B.4

npp-18

Nuclear pore complex protein

fly

P

yes

F49E10.5

ctbp-1

Transcriptional co-repressor homolog

fly

P

?

K08F8.6

let-19

Transcriptional cofactor

fly

P

yes

T17E9.1

kin-18

Serine-threonine protein kinase

fly, worm

P, T

yes

H18N23.2

-

Protein phosphatase, regulatory subunit PPP1R3C/D

fly, worm

P, SOD

?

T14F9.1

vha-15 (phi-52)

Vacuolar ATPase subunit H

worm

P, S

Yes

T21E12.4

dhc-1

Dynein heavy chain

fly, worm

P

Yes

Y113G7B.18

mdt-17

MeDiaTor

worm

S, SOD

?

Y116A8C.35

uaf-2

U2AF splicing factor

worm

P, S

Yes

F56C11.1

bli-3

Homologue of dual oxidase

worm

P, SOD

No

C32E8.10c

unc-11

Clathrin-adaptor protein AP180

worm, yeast

Aβ, P

Yes

JC8.10b

unc-26

Synaptojanin

worm, yeast

Aβ, P

Yes

ZK742.1a

xpo-1

Exportin-1

Fly, yeast

Aβ, P

?

C05C8.7

phi-49

Mannose-6-phosphate isomerase

worm

P, SOD

No


The genes were included if they were identified in more than one genetic screen. The disease models included organisms expressing forms of β-amyloid (AB), polyQ expansions (P), wild type or mutant α-synuclein (S), mutant superoxide dismutase (SOD), or mutant tau (T). Under expression in neurons a question mark indicates that no data are available in Wormbase.

Chen and Burgoyne BMC Genomics 2012 13:71   doi:10.1186/1471-2164-13-71

Open Data