Table 1

Genetic studies for the identification of regulators of neurodegeneration models in C.elegans, S. cerevisiae and D. melanogaster

Study Number

Primary model Organism

Disease model

Expressed construct

Screen

Number of Genetic modifiers

Orthologues in C. elegans

Reference


1

C. elegans

P

Htt-Q0, Q24, Q33, Q35, and Q40

Genome-wide RNAi

186

186

[10]

2

C. elegans

SOD

G85R SOD

Genome-wide RNAi

81

81

[11]

3

C. elegans

S

WT α-synuclein

Genome-wide RNAi

82

82

[9]

4

C. elegans

T

Tau P301L and V337M

Genome-wide RNAi

75

75

[14]

5

C. elegans

S

WT α-synuclein

Hypothesis-driven RNAi

20

20

[65]

6

C. elegans

P

Htt-Q150

Candidate genes

12

12

[37]

7

C. elegans

S

WT α-synuclein

Systematic RNAi screen

11

11

[68]

8

C. elegans

P

Htt-Q128

Candidate genes

4

4

[13]

9

C. elegans

1-42

Candidate genes

2

2

[69]

10

C. elegans

T

Tau P301L and V337M

Forward genetic

2

2

[70]

11

C. elegans

T

Tau V337M

Candidate genes

2

2

[71]

12

C. elegans

P

Htt-Q32, Q40, Q56, Q79

Candidate genes

2

2

[72]

13

C. elegans

P

Htt-Q2 and Q150

Candidate genes

1

1

[12]

14

S. cerevisiae

P and S

Htt-Q20, Htt-Q53, A53T α-synuclein

Genome-wide genetic

138

41

[24]

15

S. cerevisiae

S

α-synuclein

Selected genetic screen

77

20

[73]

16

S. cerevisiae

Aβ1-42

Genome-wide genetic

40

11

[60]

17

S. cerevisiae

P

Htt-Q103

Genome-wide loss-of-function suppressor

30

5

[50]

18

S. cerevisiae

S

WT α-synuclein

Genome-wide overexpression

22

7

[58]

19

S. cerevisiae

S

WT α-synuclein

Candidate genes

5

1

[59]

20

D. melanogaster

T

Tau V337M

Large-scale genetic

30

14

[74]

21

D. melanogaster

P

Htt-Q128

protein interaction and selected genetic screen

32

34

[75]

22

D. melanogaster

P

SCA182Q and Htt-Q128

Selective genetic modifier screen

24

20

[34]

23

D. melanogaster

T

Tau V337M

Large-scale genetic

24

10

[76]

24

D. melanogaster

P

Htt-Q127

Selective genetic modifier screen

10

2

[77]

25

D. melanogaster

P

SCA3trQ78

Genome-wide screen

18

17

[63]

26

D. melanogaster

P

SCA1 30Q and 82Q

Large-scale genetic

17

11

[78]

27

D. melanogaster

P

Htt-Q127

Genome-wide screen

2

1

[79]

28

D. melanogaster

S

A30P and A53T α-synuclein

Candidate gene

1

1

[80]

Total

950

675


The number of regulators of neurodegeneration that were identified in each study is shown along with the number of these genes with orthologues in C elegans. The disease models include organisms expressing forms of β-amyloid (AB), polyQ expansions (P), wild type or mutant α-synuclein (S), mutant superoxide dismutase (SOD), or mutant tau (T).

Chen and Burgoyne BMC Genomics 2012 13:71   doi:10.1186/1471-2164-13-71

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