Figure 3.

Hypothesized roles of acyl-CoA-active genes of the acetoin dehydrogenase gene cluster in P. carbinolicus. The products of acetoin dehydrogenase, acetaldehyde and acetyl-CoA, might accidentally undergo aldol addition before leaving the active site, forming either isomer of 3-hydroxybutanoyl-CoA. The methylmalonyl-CoA epimerase family protein (Pcar_0333) might convert the (R)-isomer to the (S)-isomer, which 3-hydroxyacyl-CoA dehydrogenase (Pcar_0349) can oxidize. A hydrolase/acyltransferase encoded in the cluster (Pcar_0351) might split 3-oxobutanoyl-CoA into acetate plus acetyl-CoA.

Aklujkar et al. BMC Genomics 2012 13:690   doi:10.1186/1471-2164-13-690
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