REM gliomas are more aggressive than their near-normal counterparts. REM tumors from high-grade glioma outcome-associated dataset GSE4271 are significantly more aggressive than their non-REM counterparts (logrank p<0.05). Median survivals for patients with REM (n=49) and non-REM tumors (n=29) were 77 weeks and 148 weeks, respectively. Mid-range (n=23) and near-normal (n=5) tumor groups were combined to add weight to the statistical analysis.
Wagoner and Roopra BMC Genomics 2012 13:686 doi:10.1186/1471-2164-13-686