Expression of REST signature genes in glioma tumors and non-neoplastic brain tissue. Expression REST signature genes (y-axis) are compared between 176 glioma tumors and non-neoplastic brain tissues (x-axis) from NCBI dataset GSE4290. Non-neoplastic brain tissue shows significantly greater REST target gene expression than many of the oligodendroma and astrocytomas. Average expression of normalized REST target genes is displayed below as mean +/- standard error. Oligodendromas and astrocytomas both show decreased REST target gene expression with increasing tumor grade. All heatmaps and tumor analyses were performed using MultiExperiment Viewer v4.6.
Wagoner and Roopra BMC Genomics 2012 13:686 doi:10.1186/1471-2164-13-686