Table 3

Power of mixed and unmixed study designs
Sample Size and Power
Uniform Data Design
Sib-Pair-2 900 1200 1500 1800 2100
χ2 0.37 0.48 0.52 0.55 0.57
Collapsing 0.51 0.58 0.62 0.66 0.69
VT 0.6 0.68 0.73 0.77 0.79
WSS 0.61 0.7 0.74 0.78 0.81
Nuclear Family 2 900 1200 1500 1800 2100
χ2 0.40 0.50 0.54 0.57 0.59
Collapsing 0.52 0.60 0.64 0.67 0.70
VT 0.62 0.70 0.76 0.79 0.80
WSS 0.63 0.72 0.78 0.81 0.82
Three Generation 2 900 1200 1500 1800 2100
χ2 0.44 0.53 0.57 0.6 0.63
Collapsing 0.54 0.62 0.67 0.7 0.73
VT 0.64 0.71 0.79 0.82 0.84
WSS 0.65 0.74 0.8 0.84 0.85
Mixed Data Designs
Mix1 (33% Sib-Pair-2, 33% nuclear-2, and 34% Three- generation-2) 900 1200 1500 1800 2100
χ2 0.39 0.51 0.53 0.56 0.60
Collapsing 0.53 0.59 0.64 0.68 0.70
VT 0.62 0.68 0.73 0.77 0.82
WSS 0.62 0.69 0.75 0.81 0.84
Mix2 (50% Sib-Pair-2 and 50% Nuclear Family-2) 900 1200 1500 1800 2100
χ2 0.36 0.45 0.50 0.55 0.58
Collapsing 0.49 0.55 0.59 0.63 0.65
VT 0.59 0.68 0.74 0.78 0.82
WSS 0.6 0.69 0.76 0.8 0.83

Shugart et al.

Shugart et al. BMC Genomics 2012 13:667   doi:10.1186/1471-2164-13-667

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