Table 2

Type I error rates
Study Design Nominal Level Estimated Kinship Coefficient Theoretic Kinship Coefficient Without Correction for Relatedness
Population Design with equal number of case and control 0.050 0.0515 0.0480 0.0505
0.010 0.0096 0.0099 0.0099
0.001 0.0010 0.0010 0.0010
Mixed family and case–control design 0.050 0.0504 0.0494 0.0620
0.010 0.0102 0.0097 0.0160
0.001 0.0010 0.0010 0.0015
Sib-pair-1 0.050 0.0486 0.0475 0.0813
0.010 0.0097 0.0092 0.0129
0.001 0.0010 0.0011 0.0012
Nuclear-family-1 0.050 0.0531 0.0497 0.0829
0.010 0.0093 0.0093 0.0107
0.001 0.0010 0.0009 0.0014
Three-generation-1 0.050 0.0512 0.0484 0.0874
0.010 0.0094 0.0102 0.0099
0.001 0.0010 0.0010 0.0019

5000 replicates were conducted to calculate type I error rates for each study design.

Shugart et al.

Shugart et al. BMC Genomics 2012 13:667   doi:10.1186/1471-2164-13-667

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