Additional file 14: Figure 4B.

The power curves of the family-based collapsing test (variants with frequencies 0.005 were collapsed) statistic as a function of the proportion of risk variants at the significance level α = 0.05 in the test under seven settings: unrelated individuals in cases-controls study, nuclear family groups 1 and 2, sib-pair groups 1 and 2 and three generation family groups 1 and 2, assuming an additive model, a total of 1,800 sampled individuals and a baseline penetrance of 0.01.

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Shugart et al. BMC Genomics 2012 13:667   doi:10.1186/1471-2164-13-667