Table 1

Selection of putative SCD containing Tel1/Mec1 targets
Kinetochore
Bub1 Spindle assembly protein.
Cbf2 Essential kinetochore protein, component of the CBF3 multisubunit complex.
Cnn1 Kinetochore protein of unknown function.
Mad1 Spindle assembly protein.
Spc105 Subunit of a kinetochore-microtubule binding complex that bridges centromeric heterochromatin and kinetochore. Required for kinetochore binding of SAC proteins.
Tid3 Component of the evolutionarily conserved kinetochore-associated Ndc80 complex.
Mitotic spindle
Bub2 Mitotic exit network regulator.
Nud1 Component of the spindle pole body outer plaque, required for exit from mitosis.
Spc72 Binds spindle pole bodies and links them to microtubules.
Spc97 Interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque.
Spc110 Inner plaque spindle pole body (SPB) component.
Stu1 Component of the mitotic spindle that binds to interpolar microtubules.
Cytokinesis
Cdc3 Component of the septin ring of the mother-bud neck that is required for cytokinesis.
Cla4 Involved in septin ring assembly and cytokinesis.
Cts1 Required for cell separation after mitosis.
Dse4 Degrades cell wall from the daughter side causing daughter to separate from mother.
Egt2 Required for proper cell separation after cytokinesis.
Elm1 Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis.
Cell bud
Ace2 Transcription factor that activates expression of early G1-specific genes, localizes to daughter cell nuclei after cytokinesis and delays G1 progression in daughters.
Bud3 Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis.
Bud8 Protein involved in bud-site selection.
Num1 Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip.
She3 Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud.
Cortical Actin cytoskeleton
Akl1 Ser-Thr protein kinase involved in endocytosis and actin cytoskeleton organization.
Ark1 Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton.
Bni1 Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation.
Las17 Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments.
Ndl1 Regulates dynein targeting to microtubule plus ends.
Sda1 Required for actin cytoskeleton organization.

Cheung et al.

Cheung et al. BMC Genomics 2012 13:664   doi:10.1186/1471-2164-13-664

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