Table 2

Putative miRNA-related SNPs associated with schizophrenia
mirSNP Involved gene MAFa Involved miRNAs Alleleb SCZ-associated SNP Linkagec p value OR
rs11178988 TBC1D15 0.156 hsa-miR-145-3p, hsa-miR-3680-3p, hsa-miR-5689, hsa-miR-1294 C/T rs17110426 0.945521 4.06E-06 0.6449
rs11178989 TBC1D15 0.156 hsa-miR-4501 A/C rs17110426 0.945521 4.06E-06 0.6449
rs17110432 TBC1D15 0.167 hsa-miR-1193, hsa-miR-335-3p, hsa-miR-29b-2-5p A/G rs17110426 1 4.06E-06 0.6449
rs11544338 FAM117B 0.305 hsa-miR-409-3p, hsa-miR-653 A/C/G/T rs11544338 1 5.48E-06 0.6511
rs11680951 FAM117B 0.291 hsa-miR-516a-3p, hsa-miR-376a-5p, hsa-miR-1287, hsa-miR-145-3p, hsa-miR-5191, hsa-miR-516b-3p A/C/G/T rs11544338 1 5.48E-06 0.6511
rs6058896 DNMT3B 0.078 hsa-miR-30b-5p, hsa-miR-3686, hsa-miR-30c-5p, hsa-miR-4773, hsa-miR-2278, hsa-miR-589-3p C/T rs6058894 0.946365 2.31E-05 1.584
rs10484565 TAP2 0.078 hsa-miR-3689b-5p, hsa-miR-3177-5p, hsa-miR-3689a-5p, hsa-miR-3689f, hsa-miR-190b, hsa-miR-3689e, hsa-miR-190a A/G rs10484565 1 3.58E-05 1.448
rs670358 CDC42BPG 0.395 hsa-miR-4305, hsa-miR-331-3p, hsa-miR-4638-3p, hsa-miR-4705, hsa-miR-3690, hsa-miR-5195-5p, hsa-miR-4308 A/G rs670358 1 4.68E-05 0.7677
rs11563929 STEAP2 0.1 hsa-miR-16-2-3p, hsa-miR-195-3p, hsa-miR-3942-5p, hsa-miR-4703-5p, hsa-miR-4766-3p G/T rs11563929 1 6.81E-05 0.7281
rs16870907 TAP2 0.047 hsa-miR-4760-3p, hsa-miR-330-3p C/T rs16870907 1 8.48E-05 1.589
rs12178 ZBTB34 0.456 hsa-miR-1267, hsa-miR-501-5p, hsa-miR-3613-3p, hsa-miR-653 A/C/G/T rs12178 1 9.66E-05 1.277

Eleven putative miRNA-related SNPs link to SCZ-GWAS SNPs with a significance of pā€‰<ā€‰0.0001.

aMinor allele frequencies (MAF) are from an HCB population.

bAllele reports are from NCBI.

cLinkage analysis of putative miRNA-related SNPs and SCZ-associated SNPs in 90 Asian individuals from the HapMap project.

Liu et al.

Liu et al. BMC Genomics 2012 13:661   doi:10.1186/1471-2164-13-661

Open Data