Table 1

Feature summary of the top 10% highest expressed genes in the oocysts*
Major Category(Genes #) Feature Description Representative Gene and description Signal
Enzyme (20)
  Energy (3) Glycolytic enzymes cgd7_480 Lactate dehydrogenase (LDH) 3,064.62
  Lipid (1) Membrane remodeling cgd8_1150 Choline-phosphate cytidylyltransferase 185.50
  Nucleotide (4) Nucleotide metabolic enzymes cgd5_1470 Nucleoside-diphosphate kinase domain 1,562.52
  Protein modification (9) Peptidase, kinase, phosphatase cgd7_4790 Ptc7p phosphatase (PP2C family) 333.12
Mitochondrial (2) lscU-like, F-ATPase headpiece cgd2_1360 Mitochondrial ATP synthase β-chain 351.08
Transporter (7) ABC, ion, nutrients, V-type cgd3_510 Putative fucose translocator 398.70
Stress-related (5)
  Chaperonine (3) DnaJ, HSP20, HSP90 cgd3_3770 HSP90 1,229.35
  Redox homeostasis (2) Glutaredoxin/thioredoxin related cgd2_2540 Glutaredoxin related protein 250.42
Cytoskeleton (3) Microfilament elements cgd5_3160 Actin 475.92
Membrane (7) All mucin-like proteins cgd2_430 Mucin-like glycoprotein 1,732.54
Cell cycle (1) Cyclin family protein cgd7_3780 Cyclin 318.54
Gene expression (14)
  Transcription (6) RNA Pol, transcription factors cgd3_4150 Cutinase negative acting protein 315.25
  Translation (8) Translation factors, RNA helicases, etc. cgd1_880 Eukaryotic initiation factor 4A 889.38
Protein degradation (1) Proteosome/ubiquitin subunits cgd1_420 20S proteasome beta subunit D2 168.66
Ribosome biogenesis (38)
  Ribosomal proteins (32) RPL, RPS, or associated proteins cgd3_2250 60S ribosomal protein L37A 303.99
  rRNA processing (6) GTPase, ribonucleoprotein, etc. cgd4_1700 GNog1p. GTPase 276.15
RNA metabolism (11) Methylase, Helicase, RNA-splicing, RNA-binding, etc. cgd7_940 T22E16.120 SC35-like splicing factor 871.81
DNA metabolism (2) Methytranferase, DNA-binding cgd2_3070 HMG-box protein 425.65
Unknown (82)
  Conserved domains (18) Conserved domain-containing cgd2_200 Possible apicomplexan-specific protein 1,742.09
  Membrane (15) Predicted membrane proteins cgd6_780 Predicted extracellular protein 849.61
  Unknown (49) Hypothetical/unknown cgd3_1570 Unknown, possible sporozoite antigen 1,957.29

* A list of genes with detailed information on the normalized expression levels, their ranks, and categories is provided in Additional file 2, Table S1.

Zhang et al.

Zhang et al. BMC Genomics 2012 13:647   doi:10.1186/1471-2164-13-647

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