Table 2

Putative LEF1/TCF target genes that encode proteins with specific neuronal functions
No. Gene symbol (RGD) Protein name; description
Voltage-gated cation channels
1 Cacna1g Ca2+ channel, voltage-gated, α1G subunit
2 Cacna2d1 Ca2+ channel, voltage-gated, α2/δ1 subunit
3 Cacna2d2 Ca2+ channel, voltage-gated, α2/δ2 subunit
4 Kcna1 K+ voltage-gated, shaker-related subfamily member 1
5 Kcna6 K+ voltage-gated, shaker-related subfamily member 6
6 Kcnh4 K+ voltage-gated, subfamily H member 4
7 Kcnh8 K+ voltage-gated, subfamily H member 8
8 Kcnj3 K+ inwardly rectifying channel, subfamily J member 3
9 Scn8a Na+ voltage-gated, type VIII, alpha subunit
Neurotransmitter receptors
10 Cnr1 Cannabinoid CB1 receptor; metabotropic
11 Drd3 Dopamine D3 receptor; metabotropic
12 Gabra3 GABAAα3 receptor; ionotropic (Cl-)
13 Gabrg2 GABAAγ2 receptor; ionotropic (Cl-)
14 Glra1 Glycine α1 receptor; ionotropic
15 Gria3 Glutamate AMPA 3 receptor; ionotropic
16 Grid2 Glutamate δ2 receptor; ionotropic
17 Grik3 Glutamate kainate 3 receptor; ionotropic
18 Htr1b 5-hydroxytryptamine (serotonin) 1B receptor; metabotropic
19 Htr3a Serotonin 3A receptor; ionotropic
20 Htr3b Serotonin 3B receptor; ionotropic
Synaptic vesicle proteins
21 Syt1 Synaptotagmin I; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release
22 Syt4 Synaptotagmin IV; membrane protein, vesicle trafficking and neurotransmitter release
23 Syt5 Synaptotagmin V; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release
24 Syt6 Synaptotagmin VI; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release
25 Syt7 Synaptotagmin VII; membrane protein, Ca2+ sensor involved in vesicle trafficking and neurotransmitter release
26 Syp Synaptophysin; synaptic vesicle organization
27 Vamp2 Vesicle-associated membrane protein 2; vesicle transport and membrane fusion during exocytosis
28 Vamp3 Vesicle-associated membrane protein 3; vesicle transport and membrane fusion during exocytosis
Structural synaptic proteins
29 Cdh2 Cadherin 2 (alias N-cadherin); hemophilic cell adhesion molecule in excitatory synapses
30 Cnksr2 Connector enhancer of kinase suppressor of Ras 2; scaffold protein, complex assembly of synaptic proteins
31 Dfnb31 Deafness autosomal recessive 31; PDZ scaffold protein, facilitates synaptic transmission
32 Gabarap GABAA receptor-associated protein; involved in clustering of neurotransmitter receptors
33 Lin7a Homolog a of C. elegans lin-7; PDZ scaffold protein, localizes vesicles and receptors to the plasma membrane
34 Map1b Microtubule-associated protein; involved in synaptic plasticity
35 Mpdz Multiple PDZ domain protein; PDZ scaffold protein, component of NMDA receptor signaling complex
36 Nlgn1 Neuroligin 1; synaptic cell adhesion molecule, maintains synaptic junctions by binding β-neurexins
37 Nlgn2 Neuroligin 2; synaptic cell-adhesion molecule, maintains synaptic junctions by binding β-neurexins
38 Nrxn3 Neurexins 3; synaptic cell-adhesion molecule; maintains synaptic junctions by binding neuroligins
Other proteins involved in modulation of signal transmission
39 Gjd2 Gap junction protein delta; member of the connexin family, in gap-junction channels of electrical synapses
40 App Amyloid β (A4) precursor protein; cell surface receptor involved in synaptic plasticity
41 Calb2 Calbindin 2 (alias calretinin); Ca2+-binding protein, modulates neuronal excitability

The gene symbols are based on the Rat Genome Database (RGD).

Wisniewska et al.

Wisniewska et al. BMC Genomics 2012 13:635   doi:10.1186/1471-2164-13-635

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