Table 1

Canonical Pathways enriched in mouse, macaque and swine CA04 infection models
Infection model Canonical pathway B-H p-value mola/molb
Mouse Acute Phase Response Signaling 2.34E-10 28/177
LXR/RXR Activation 2.34E-10 26/136
Atherosclerosis Signaling 3.47E-09 22/129
Hepatic Fibrosis / Hepatic Stellate Cell Activation 6.31E-07 21/147
IL-12 Signaling and Production in Macrophages 1.12E-06 20/155
Complement System 4.07E-06 10/35
Type I Diabetes Mellitus Signaling 5.50E-06 17/121
Nitrogen Metabolism 8.51E-05 9/120
Clathrin-mediated Endocytosis Signaling 1.30E-04 20/195
Dendritic Cell Maturation 1.70E-04 18/185
Macaque VDR/RXR Activation 3.63E-03 13/81
Hematopoiesis from Pluripotent Stem Cells 5.25E-03 10/64
Communication between Innate and Adaptive Immune Cells 2.75E-02 12/109
Type I Diabetes Mellitus Signaling 3.16E-02 13/121
Altered T Cell and B Cell Signaling in Rheumatoid Arthritis 3.80E-02 11/92
Gα12/13 Signaling 3.80E-02 13/127
Neuroprotective Role of THOP1 in Alzheimer's Disease 3.80E-02 7/54
Hematopoiesis from Multipotent Stem Cells 3.80E-02 4/12
Primary Immunodeficiency Signaling 3.80E-02 8/63
Pyrimidine Metabolism 3.80E-02 14/215
Swine LXR/RXR Activation 1.15E-07 20/136
Nitrogen Metabolism 9.33E-04 8/120
Antigen Presentation Pathway 9.33E-04 8/40
Communication between Innate and Adaptive Immune Cells 9.33E-04 12/109
Hepatic Fibrosis / Hepatic Stellate Cell Activation 9.33E-04 15/147
Type I Diabetes Mellitus Signaling 9.33E-04 13/121
Primary Immunodeficiency Signaling 9.33E-04 9/63
Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses 9.33E-04 12/106
TREM1 Signaling 9.33E-04 9/66
Atherosclerosis Signaling 1.12E-03 13/129

Ingenuity Pathway Analysis was used to determine the top 10 Canonical Pathways. Benjamini-Hochberg (B-H) Multiple Testing Correction p-value was used to rank the significance associated for each pathway.

a Number of molecules differentially expressed in the Canonical Pathway.

b Total number of molecules in the annotated Canonical Pathway.

Go et al.

Go et al. BMC Genomics 2012 13:627   doi:10.1186/1471-2164-13-627

Open Data