Table 1

Spalax hypoxia induced genes belonging to selected enriched terms
Blood vessel development Enzyme linked receptor S1pr1 2 Icam1 2 Fntb 3 Gna13 2
Plaur 2 Serpine1 2 Btg1 4 Pecam1 6
Nrip1 2 Tlr4 2 Loc100046643 4 Ppara 3
Acvrl1 5 Acvrl1 5 Fzd4 2 C3ar1 2 Zbtb16 5 Serping1 2
Col18a1 3 Ltbp1 2 Arntl 2 Serpina5 4 Positive regulation of cell differentiation Tollip 2
Pgf 2 Tiam1 4 Kdr 5 Oasl1 2 F5 2
Hmox1 2 Axl 2 Thbd 4 Plaur 2 F3 2
Epha2 2 Epha2 2 Egf like Cfi 2 Tiam1 4 Tnfrsf1b 2
Ctnnb1 2 Arid5b 3 Ltbp1 2 B2m 4 Igfbp3 6 Pf4 2
Cav1 3 Ctgf 3 Lamb1-1 3 Cxcl12 4 Id2 3 Cxcl1 4
Ctgf 3 Vegfa 6 Epha2 2 Thbd 4 Tnfrsf12a 4 Tgfbr2 2
Gna13 2 Nrp1 2 Hyal2 3 Bnip3 4 Cd74 3 Myd88 2
Trp63 3 Eng 3 Lama2 3 Negative regulation of apoptosis Inpp5d 4 Fntb 3
Hes1 2 Skil 2 Vcan 2 Ets1 5 Nfkbiz 4
Adamts1 5 Egf 2 Plau 3 Btg1 4 Tlr4 2
Tnfrsf12a 4 Pdgfra 5 Thbs2 4 Angptl4 6 H2-aa 4 Loc640441 3
Vegfa 6 Tgfbr3 3 Itgb1 2 Bcl2l1 3 Foxo3 3 Plaur 2
Nrp1 2 Flt1 6 Lamc2 2 Btg2 3 Junb 3 Gja1 3
Eng 3 Eif4ebp1 2 Pamr1 3 Bnip3l 2 Socs3 5 Cfi 2
Dll4 2 Adam9 2 Dll4 2 Myc 5 Brlz Sphk1 3
Egf 2 Tgfbr2 2 Cd93 3 Trp63 3 Mafk 3 Thbd 4
Cyr61 3 Myd88 2 Egf 2 Cdkn1a 4 Bach1 3 Sex dev.
Nr4a3 2 Csrnp1 4 Pear1 4 Vegfa 6 Atf3 4 Acvrl1 5
Nos3 3 Tiparp 3 Tnc 2 Pim1 3 Fosl2 3 Lamb1-1 3
Pdgfra 5 Smad6 2 Mfge8 3 Cd74 3 Maff 5 Pafah1b2 3
Tgfbr3 3 Plekha1 2 Adam9 2 Snca 2 Junb 3 Ctnnb1 2
Flt1 6 Ltbp4 2 Eltd1 4 Csda 2 Cebpb 5 Cav1 3
Mgp 2 Pik3r1 3 Loc640441 3 Bag3 2 Cebpd 6 Bcl2l1 3
Mfge8 3 Foxo1 5 Ltbp4 2 Tsc22d3 4 Mafb 3 Sirt1 3
Adm 3 Kdr 5 Clec14a 3 Agt 2 C2h2 like Spata9 3
Col4a1 5 Receptors Ptgs1 2 Gclc 2 Rnf166 3 Dab2 6
Col4a2 5 Acvrl1 5 Thbd 4 Cited2 3 Zkscan17 3 Trp63 3
Cdh5 3 Axl 2 Heg1 2 Pik3r1 3 2810021j22rik 2 Adamts1 5
Agt 2 Cd36 2 Growth factor binding Foxo1 5 Hinfp 5 Vegfa 6
Robo4 3 Gab2 2 Cebpb 5 Zfp661 4 Sf1 3
Tgfbr2 2 Pgrmc1 3 Sphk1 3 Zfp39 3 Itgb1 2
Tiparp 3 Epha2 2 Ltbp1 2 Bnip3 4 Zfp750 2 Xrn2 3
Twist1 2 Hyal2 3 Htra1 3 Prnp 3 Zfp691 3 Ccna1 2
Btg1 4 Mertk 2 Igfbp4 2 Negative regulation of cell differentiation Gm6766 4 Cyr61 3
Adamts2 2 Scara5 2 Ctgf 3 Zfp512 2 Tnc 2
Loc100046643 4 Ednrb 2 Igfbp3 6 Krab Nos3 3
Cited2 3 Osmr 3 Eng 3 Ctnnb1 2 Zkscan17 3 Pdgfra 5
Loc640441 3 Ppara 3 Cyr61 3 Cav1 3 2810021j22rik 2 Tgfbr3 3
Zc3h12a 2 Il15ra 3 Pdgfra 5 Sirt1 3 Zfp661 4 Csda 2
Foxo1 5 Tnfrsf12a 4 Tgfbr3 3 Nfkbia 4 Zfp39 3 Tead4 3
Shb 4 Itgb1 2 Col4a1 5 Trp63 3 Pogk 4 Adm 3
S1pr1 2 Nrp1 2 Ltbp4 2 Hes1 2 Btb / btb poz Sfrp1 2
Gja1 3 Fcgr2b 3 Kdr 5 Rcan1 4 Kctd2 2 Agt 2
Junb 3 Mrc1 2 Immune Response Cd74 3 Zbtb4 3 Egln1 3
Socs3 5 Slc20a1 2 Vwf 2 Itgb1 2 Rhobtb1 2 Cadm1 2
Rhob 4 Cd93 3 Gadd45g 4 Nrp1 2 Btbd11 2 Klf9 4
Cxcl12 4 Trpc4 2 Cxcl14 3 Inpp5d 4 Rhobtb2 2 Adamts2 2
Sphk1 3 Ptgfrn 4 Plau 3 Skil 2 Loc100046682 3 Siah1a 4
Kdr 5 Nr4a3 2 Bnip3l 2 Wwtr1 6 Ipp 2 Slc30a1 5
Ecm receptor interaction Tnfrsf1b 2 Serping1 2 Tgfbr3 3 Klhl8 2 Cited2 3
Errfi1 5 Vegfa 6 Pf4 2 Kbtbd8 2 Serpina5 4
Pdgfra 5 Cd74 3 Rnf6 2 Klhdc5 3 Maff 5
Vwf 2 Tgfbr3 3 Tollip 2 Twist1 2 Zbtb38 2 Nrip1 2
Lamb1-1 3 Flt1 6 Inpp5d 4 Pik3r1 3 Kctd21 4 Foxo3 3
Cd36 2 Robo4 3 F5 2 Zfp36 2 Gm6766 4 Aff4 2
Sdc4 2 Tgfbr2 2 Fcgr2b 3 Zbtb16 5 Gm14457 3 Gja1 3
Lama2 3 Lpar1 2 F3 2 Cav1 3 Zbtb12 2 Junb 3
Thbs2 4 Tlr4 2 Tnfrsf1b 2 Igfbp3 6 Spop 2 Socs3 5
Itgb1 2 Eltd1 4 Tinagl1 4 Cdkn1a 4 Loc638050 2 Kdm3a 3
Col5a2 2 Pnrc1 3 Pf4 2 Sf1 3 Wounding Cebpb 5
Lamc2 2 C3ar1 2 Cxcl1 4 Inpp5d 4 Klf6 4 Cxcl12 4
Tnc 2 Chrnb1 2 Cadm1 2 Fcgr2b 3 Vwf 2 Ppp1r1b 2
Col4a1 5 Cmklr1 3 Myd88 2 Nos3 3 Entpd2 2 Kdr 5
Col4a2 5 Gm5898 2 Sbno2 2 Tgfbr3 3 Igfbp4 2 Zbtb16 5
Loc640441 3 Cxcr7 5 H2-aa 4 Cdh5 3 Map2k3 4 Thbd 4

The number of conditions in which significant over/underexpression was detected in the microarray is shown to the right of the gene symbol, for 215 different genes. The list is based on Additional file 3: Tables S3 and Additional file 4: Table S4 for genes with unambiguous annotations. Group titles in bold, represent specific functional terms or groups of synonymous terms. Sex dev. Denotes reproductive development. Enzyme linked receptor denotes enzyme linked receptor signaling pathway. Brlz denotes basic leucine zipper TF.

Malik et al.

Malik et al. BMC Genomics 2012 13:615   doi:10.1186/1471-2164-13-615

Open Data