Open Access Research article

Transcriptome analysis of the spalax hypoxia survival response includes suppression of apoptosis and tight control of angiogenesis

Assaf Malik1, Abraham Korol1, Mathias Weber2, Thomas Hankeln2, Aaron Avivi1 and Mark Band3*

Author Affiliations

1 Institute of Evolution, University of Haifa, Haifa, Israel

2 Institute of Molecular Genetics, Johannes Gutenberg University, Mainz, Germany

3 W.M. Keck Center for Comparative and Functional Genomics, University of Illinois, Urbana, Illinois, USA

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BMC Genomics 2012, 13:615  doi:10.1186/1471-2164-13-615

Published: 13 November 2012

Additional files

Additional file 1:

Table S1. RLT-q-PCR primers.

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Additional file 2:

Table S2. Limma differential expression statisitcs. Spalax differential expression statistics for mu3/6/10 and br3/6/10, mapped to mouse genes (Ensembl gene IDs), and Spalax contig. Expression fold change, FDR p-value and ontology terms are presented.

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Additional file 3:

Table S3. GO terms enriched among Spalax genes differentially expressed in >=1, >=2, and >=3 experiments. The table includes DAVID enrichment profiles for Spalax probes which map to unique reference genes (unabiguous genes) as well as all probes. Terms passing an enrichment theshold of FDR 0.05 are highlighted in bold.

Format: XLSX Size: 597KB Download file

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Additional file 4:

Table S4. GO terms enriched among Spalax genes differentially expressed in both mu3 and br3. The table includes DAVID enrichment profiles both for all data and for filtered data (after excluding probes mapped to Spalax contigs with ambiguous annotations). Terms eriched with FDR 0.05 are highlighted in bold.

Format: XLSX Size: 95KB Download file

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Additional file 5:

Table S5. GO terms enriched among Spalax genes differentially expressed in mu3, mu6, mu10, br3, br6 and br10. The table includes DAVID enrichment profiles for all data.

Format: XLSX Size: 510KB Download file

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Additional file 6:

Table S6. GO terms enriched among Spalax genes differentially expressed in mu3, mu6, mu10, br3, br6 and br10. The table includes DAVID enrichment profiles for filtered data (after excluding probes mapped to Spalax contigs with ambiguous annotations).

Format: XLSX Size: 413KB Download file

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Additional file 7:

Table S7. GO terms enriched among rat genes differentially expressed in mu6, and br6. The table includes DAVID enrichment profiles for all rat data.

Format: XLSX Size: 87KB Download file

Open Data