Analysis of disseminated tumor cells (DTCs) with multi-sample PCF. The top panel shows the primary tumor and the three panels below show single cells morphologically classified as DTCs (all for chromosome 2). High noise levels make separate analyses of each DTC difficult; co-analyzing multiple DTCs, possibly together with a primary tumor, thus facilitates an evaluation of the degree of correspondence between the aberration patterns. In the present case, two DTCs seem to have aberration patterns similar to the primary tumor, while the last cell has an essentially flat (balanced) pattern and is probably a hematopoietic cell misclassified as a DTC. The plot was created with the function plotChrom in copynumber.
Nilsen et al. BMC Genomics 2012 13:591 doi:10.1186/1471-2164-13-591