Comparison of results from single sample and multi-sample PCF. In single sample PCF, γ=40 was used, while in multi-sample PCF, γ=120 was used to limit the number of segments. Note that the estimated aberration patterns are quite similar; indicating that the multi-sample PCF estimates (panel b) should be well suited as variables in statistical analyses. On a more detailed level there are differences, e.g., longer segments in the single sample analysis (panel a) are divided into subsegments with slightly different estimates in the multi-sample analysis. The plot was created with the function plotHeatmap in copynumber.
Nilsen et al. BMC Genomics 2012 13:591 doi:10.1186/1471-2164-13-591