Analyses of bidirectionally modulated genes in multiple cell types. The intersection of bidirectionally-modulated genes identifies genes modulated by both increased miR-181b expression (miR treatment) and miR-181b inhibition (anti-miR-181b treatment) in each cell type. Genes modulated by either miR-181b over-expression or inhibition were considered for the union of modulated genes across multiple cell types. The subsequent KEGG pathways analyses on these genes of interest revealed significantly enriched pathways, as evident in the bottom half of this figure.
Carroll et al. BMC Genomics 2012 13:561 doi:10.1186/1471-2164-13-561