Bivalent domains on transcriptional regulators are altered by MD. H3K4me3 (orange) and H3K27me3 (green) profiles and associated transcript levels of BCL6 (A, B), EGR1 (C, D) and CITED2 (E, F). In all three cases we observe a slight increase in H3K27me3 induced by MDV infection in line 72 and a concurrent significant decrease in transcript levels while increase in active and repressive marks appear to cancel each other out in line 63.
Mitra et al. BMC Genomics 2012 13:557 doi:10.1186/1471-2164-13-557