Table 1

Differentially expressed miRNAs in infarcted tissue compared to corresponding remote myocardium, their classification (from miRBase) and prediction of targeting SERCA2 (PicTar, TargetScan, miRanda, mirTarget2)
miRNA average log2 average log2* predicted miRNA Gene family

Clustered

(chr: miR; location)

let-7b 0.04 −0.32 Yes let-7 22: let-7a-3, miR-4763; intronic
let-7c −0.87 −0.88 Yes let-7 21: miR-99a; intronic
let-7d −1.34 −1.33 Yes let-7 9: let-7a-1, let-7f-1; intronic
let-7g −1.50 −1.67 Yes let-7 3: as single gene; intronic
miR-1 −3.28 −1.89 No miR-1 18: miR-133a-1; intronic
20: miR-133a-2; intronic
miR-122 3.28 ND No miR-122 18: miR-3591; intergenic
miR-125a-5p −1.53 −1.46 No miR-125 19: let-7e, miR-99b; intronic
miR-125b −0.44 −0.47 No miR-125 11: as single gene; intronic
miR-126 −2.00 −0.50 No miR-126 9: as single gene; intronic
miR-133a −1.52 ND No miR-133 18: miR-1-2; intronic
20: miR-1-1; intronic
miR-133b −1.53 ND No miR-133 6: miR-206; intronic
miR-140-3p 0.32 ND No miR-140 16: as single gene; intronic
miR-143 −0.26 ND No miR-143 5: miR-145; intergenic
miR-145 −0.79 ND No miR-145 5: miR-143; intergenic
miR-150 −1.63 −1.60 No miR-150 19: as single gene; intergenic
miR-16 −0.03 ND No miR-15 13: miR-15a; intronic
3: miR-15a; intronic
miR-195 −0.51 −1.37 Yes miR-15 17: miR-497; intronic
miR-197 −0.57 ND No miR-197 1: as single gene; intergenic
miR-199a-3p 0.39 ND No miR-199 19: as single gene; intronic
1: miR-199a-2, miR-3120, miR-214; intronic
miR-19b −2.36 ND Yes miR-19 13: miR-17, miR-18a, miR-19a, miR-20a, miR-92a-1; intergenic
X: miR-106a, miR-18b, miR-20b, miR-92a-2, miR-363; intergenic
miR-21 −0.05 ND No miR-21 17: as single gene; intergenic
miR-23a −1.71 −0.20 No miR-23 19: miR-27a, miR-24-2; intergenic
miR-26a −1.50 −0.54 No miR-26 3: as single gene; intronic
12: as single gene; intronic
miR-27a −1.97 −1.60 No miR-27 19: miR-23a, miR-24-2; intergenic
miR-27b −2.18 −1.19 No miR-27 9: miR-23b, miR-24-1, miR-3074; intronic
miR-29a −1.40 ND Yes miR-29 7: miR-29b-1; intergenic
miR-29c −2.28 ND No miR-29 1: miR-29b-2; intergenic
miR-30a −2.23 −1.25 Yes miR-30 6: as single gene; intronic
miR-30b −3.03 −2.01 Yes miR-30 8: miR-30d; intergenic
miR-30c −2.70 −2.08 Yes miR-30 1: miR-30e; intronic
6: as single gene; intronic
miR-30d −1.31 ND Yes miR-30 8: miR-30b; intergenic
miR-30e −2.71 ND Yes miR-30 1: miR-30c-1; intronic
miR-320a 2.37 0.98 No miR-320 8: as single gene; intergenic
miR-320b 2.24 0.98 No miR-320 1: two copies as single gene; one intronic
and one intergenic
miR-320c 2.27 0.98 No miR-320 18: two copies as single gene; intronic
miR-320d 2.13 0.98 No miR-320 13: as single gene; intergenic
X: as single gene; intergenic
miR-378 −1.66 ND No miR-378 5. as single gene; intronic
miR-483-5p 2.92 ND No miR-483 11: as single gene; intronic
miR-499-5p −2.94 −3.36 Yes miR-499 20: miR-499a; intronic
miR-574-3p 2.25 2.46 Yes miR-574 4: as single gene; intronic
miR-574-5p 2.17 3.18 No miR-574
miR-98 −1.76 −3.10 Yes let-7 X: let-7f; intronic

Legend: *, results from previous microarray study [11], where infarcted tissue was compared to healthy adult hearts (independent groups of samples); ND, not determinate; chr, chromosome.

Boštjančič et al.

Boštjančič et al. BMC Genomics 2012 13:552   doi:10.1186/1471-2164-13-552

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