Open Access Research article

Ubiquitous Gasp1 overexpression in mice leads mainly to a hypermuscular phenotype

Olivier Monestier12, Caroline Brun12, Katy Heu12, Bruno Passet3, Mélanie Malhouroux12, Laetitia Magnol12, Jean-Luc Vilotte3 and Véronique Blanquet12*

Author Affiliations

1 INRA, UMR1061 Unité de Génétique Moléculaire Animale, Limoges, 87060, France

2 Université de Limoges, Limoges, 87060, France

3 INRA, UMR1313 GABI Génétique Animale et Biologie Intégrative, Jouy-en-Josas, 78352, France

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BMC Genomics 2012, 13:541  doi:10.1186/1471-2164-13-541

Published: 10 October 2012

Additional files

Additional file 1:

Fiber type distribution in quadriceps of surGasp-1 mice. No significant variation in proportion of type I (dark grey) or type II fibers (light grey) was observed in surGasp1-20, surGasp1-06 mice when compared to wild-type. Data are expressed +/-SEM.

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Additional file 2:

Neonatal expression of Gasp-1 and myogenic regulatory factors. mRNA expression levels were determined by qRT–PCR relative to the reference genes Gapdh and TfIID in extracts from head (dark grey, n = 3) or hindlimb (light grey, n = 3) of postnatal 3 days surGasp1-20 animals. The horizontal dashed line represents a twofold increase in expression level.* : p < 0.05 ; ** : p < 0.01.

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Additional file 3:

Table 1: List of the 96 genes that were measured on the TaqMan Low Density Arrays.

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