Table 4

Regulation of key immune response related genes in guinea pig lungs infected with M. tuberculosis
Pathway Up Down
Chemokine signaling pathway GNB4, RAC1, IL8, GNG5, HCK, RAC2, FOXO3, RAP1B, SOS2, ADRBK1, NCF1, GNAI2, CCL27, VAV3, RHOA, ADCY4, ARRB2, NFKBIB GNB1, PLCB3, CCL5, CXCL9, RAP1A, CXCR3, GNG8, GNG2, CCL21, AKT3, CRKL, MAPK1, PRKACG, PRKACA, CHUK, CCL11, BRAF, MAP2K1, RASGRP2
Cell adhesion molecules (CAMs) HLA-DQB1, ITGB7, HLA-A, HLA-B, HLA-B, HLA-DMA, NRXN2, HLA-DPA1, HLA-DRB1, HLA-DRB1, ALCAM, CLDN18, CLDN14 MPZL1, HLA-E, HLA-F, CADM3, CADM1, CD34, CD8A, CD99, CDH3, CLDN4, CLDN6, NCAM1, GLG1, NLGN2, ITGB2, ITGB8, ITGA9, CNTNAP1, SIGLEC1
Cytokine-cytokine receptor interaction IL1, RAP, IL8, TGFB1, IL1B, CSF1R, IL23A, BMP8A, CCL27, BMP4, BMPR2 GHR, CCL5, CD70, CXCL9, KIT, CD27, CXCR3, TNF╬▒, IL2RG, CNTFR, BMPR1A, IL23R, CCL21, TGFB3, FLT4, BMP5, IFNGR2, LTA, IL9, CCL11, TNFSF10, ACVR2A
Leukocyte trans-endothelial migration RAC1, CYBA, CYBB, RAC2, RAP1B, ACTG1, NCF1, GNAI2, EZR, ACTN4, VAV3, RHOA, PTPN11, CLDN18, CLDN14, ACTB RAP1A, CD99, RHOH, THY1, MAPK11, CTNNB1, CLDN4, CLDN6, ITGB2, MLLT4, PLCG1
Natural killer cell mediated cytotoxicity RAC1, ARAF, HLA-A, HLA-B, RAC2, SOS2, VAV3, LAT, FCER1G, PTPN11, MAP2K2, PTPN6 TYROBP, HLA-E, HLA-F, TNF, IFNGR2, MAPK1, PPP3CB, GZMB, ITGB2, TNFSF10, BRAF, MAP2K1, PLCG1
T cell receptor signaling pathway SOS2, GRAP2, VAV3, LAT, RHOA, NFKBIB, MAP2K2, PTPN6, PAK2 CD8A, FOS, TNF, NCK1, AKT3, MAPK11, MAPK1, PPP3CB, CHUK, MAP2K1, PLCG1
B cell receptor signaling pathway RAC1, RAC2, SOS2, CD81, VAV3, LILRB3, NFKBIB, MAP2K2, PTPN6, CR2 FOS, AKT3, MAPK1, PPP3CB, CHUK, MAP2K1
Antigen processing and presentation HLA-DQB1, HLA-A, HLA-B, HLA-B, CD74, HLA-DMA, HLA-DPA1, HLA-DRB1, HLA-DRB1, HSP90AB1, CTSB, CTSS, HSP90AA1 HLA-E, HLA-F, CD8A, TNF, TAPBP, HSPA5, PSME2
Complement and coagulation cascades C4A, C3, C1S, SERPING1, CR2 CD55, MASP2, KNG1, SERPINC1, F8, C9, C6, C3AR1, C5AR1

Jain et al.

Jain et al. BMC Genomics 2012 13:520   doi:10.1186/1471-2164-13-520

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