Additional file 2.

Pulmonary gene expression signature of guinea pigs at 10 weeks post M. tuberculosis infection. The figure depicts the clustered heat maps for all the genes on the 44 K GPOM in case of infected guinea pigs compared to uninfected control. By using unsupervised hierarchical clustering algorithm, the most similar expression profiles are joined together to form a group. These are further joined in a tree structure, until all data forms a single group. Clustering is based on averaged distance between two clusters, which is the average of the pair-wise distance between entities in the two clusters. For measurement of similarity between conditions, Pearson coefficient correlation clustering algorithm is used. The color scheme for the hierarchical clustering is - yellow: no change in expression, magenta: higher expression in infected lungs relative to normal lungs and green: lower expression in infected samples relative to normal uninfected lungs. 1: Uninfected control; 2: Infected Lung 1; 3: Infected Lung 2; 4: Infected Lung 3.

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Jain et al. BMC Genomics 2012 13:520   doi:10.1186/1471-2164-13-520