Table 1

Summary results for the validated follicular lymphoma associated single-nucleotide polymorphisms
SNP Gene(s) within 5 kb (hg18) LOC (hg18) A1/A2 SF-NHL2 GWAS SCALE GWAS SF-NHL1 Validation Combined meta-analysis
Logistic p-value Logistic OR (95% CI) MAF ca/co Logistic p-value Logistic OR (95% CI) MAF ca/co Logistic p-value Logistic OR (95% CI) MAF ca/co P-value* OR* (95% CI) Q I2
rs9275517 - chr6 32782627 A/G 7.56E-04 0.67 (0.53- 0.85) 0.29/0.38 6.73E-07 0.63 (0.53-0.76) 0.37/0.48 2.32E-03 0.57 (0.39-0.82) 0.29/0.41 4.03E-11 0.63 [0.55-0.73] 0.7596 0% (0%-62.2%)
rs3117222 HLA-DPB1, Q30181 chr6 33168927 A/G 4.17E-03 0.67 (0.51- 0.88) 0.18/0.25 3.06E-04 0.68 (0.55-0.84) 0.19/0.26 5.72E-03 0.58 (0.39-0.85) 0.16/0.25 1.45E-07 0.66 [0.57-0.77] 0.7673 0% [0%-60.7%]

*P-values and ORs estimated from the meta-analysis were identical for the random- and fixed-effects models.

A1/A2 = minor/major alleles; Q = Cochran’s Q statistic; I2 = heterogeneity index.

Skibola et al.

Skibola et al. BMC Genomics 2012 13:516   doi:10.1186/1471-2164-13-516

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