Open Access Research article

Genetic structure of community acquired methicillin-resistant Staphylococcus aureus USA300

Ryan Tewhey123, Christopher R Cannavino456, John AD Leake45, Vikas Bansal1, Eric J Topol12, Ali Torkamani12, John S Bradley45* and Nicholas J Schork12*

Author Affiliations

1 Scripps Genomic Medicine, Scripps Translational Science Institute, La Jolla, CA, USA

2 Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, CA, USA

3 Division of Biological Sciences, University of California, San Diego, La Jolla, CA, USA

4 Department of Pediatrics, Division of Infectious Diseases, Rady Children’s Hospital San Diego, San Diego, CA, USA

5 Department of Pediatrics, Division of Infectious Diseases, University of California, San Diego, CA, USA

6 Department of Pediatrics, Division of Hospital Medicine, Rady Children’s Hospital San Diego, San Diego, CA, USA

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BMC Genomics 2012, 13:508  doi:10.1186/1471-2164-13-508

Published: 25 September 2012

Additional files

Additional file 1:

Table S1.Patient characteristics of sequence isolates by study group. Table S2: Clinical diagnoses of included CA-MRSA severe infections. Table S3: Site of included CA-MRSA severe infections. Table S4: Nucleotide mutation catagories. Table S5: Variants exhibiting convergent evolution. Table S6: Protein Altering Single Nucleotide Variants.

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Additional file 2:

Figure S1.Pangenomic representation of all 36 clinical isolates relative to the USA300 FPR3757 reference.

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