Open Access Highly Accessed Research article

Comparative exome sequencing of metastatic lesions provides insights into the mutational progression of melanoma

Jared J Gartner1, Sean Davis2, Xiaomu Wei1, Jimmy C Lin3, Niraj S Trivedi7, Jamie K Teer4, NISC Comparative Sequencing Program5, Paul S Meltzer2, Steven A Rosenberg6 and Yardena Samuels1*

Author Affiliations

1 The Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA

2 The Genetics Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

3 Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA

4 Genetic Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA

5 NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA

6 The Surgery Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20892, USA

7 Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA

For all author emails, please log on.

BMC Genomics 2012, 13:505  doi:10.1186/1471-2164-13-505

Published: 24 September 2012

Additional files

Additional file 1:

Table S1. Is a table listing the relevant clinical information for the patients in each set.

Format: XLSX Size: 14KB Download file

Open Data

Additional file 2:

Table S2. Is a complete list of variants found in our whole exome capture of the 98 set.

Format: XLSX Size: 39KB Download file

Open Data

Additional file 3:

Table S3. Is a complete list of variants found in our whole exome capture of the 130 set.

Format: XLSX Size: 55KB Download file

Open Data

Additional file 4:

Figure S1. Contains Results of qPCR validation.

Format: PDF Size: 172KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 5:

Table S4. Is a complete list of pathways found to be enriched in each individual tumor sample.

Format: XLSX Size: 14KB Download file

Open Data

Additional file 6:

Table S5. Is a summary of sequencing statistics for each tumor.

Format: XLSX Size: 10KB Download file

Open Data

Additional file 7:

Table S6. Is summary of pseudo-CGH windows used for deriving copy number from our exome sequencing.

Format: XLSX Size: 9KB Download file

Open Data

Additional file 8:

Table S7. Is complete list of primers used to evaluate our CNV data trough real time PCR.

Format: XLSX Size: 12KB Download file

Open Data