Table 2

Agonistically linked traits
Disease Abbr. Agonistically Linked Traits (Loci) #
CROHN DISEASE CD UC (1p31, 1q32, 3p21, 5p13, 9p24, 9q32, 9q34, 10q24, 21q21, 21q22); IBD (1p31, 9q32, 10q22, 16q12, 20q13, 22q12); CeD (2q12, 18p11, 22q11); LEP (9q32, 13q14); MG (22q12); T1D (1q32, 18p11); SC (3p21); OVARIAN NEOPLASMS (8q24); AS (1p31); LL (2q37); HTG (2p23); AA (11q13); MS (10p15); AD (11q13) 14
ARTHRITIS, RHEUMATOID RA CeD (1p36, 4q27, 6q23); SLE (2q32, 7q32, 8p23); T1D (2q33, 4p15, 21q22); BLC (7q32); SS (7q32); FL (6p21); UC (6q23); LBL (6p21); SCHIZOPHRENIA (6p21); VIT (21q22) 10
CELIAC DISEASE CeD CD (2q12, 18p11, 22q11); RA (1p36, 4q27, 6q23); UC (2p16, 6q23); T1D (18p11); BLC (7p14); VIT (3q28); HYP (12q24); SLE (6p21); MG (6p21) 9
COLITIS, ULCERATIVE UC CD (1p31, 1q32, 3p21, 5p13, 9p24, 9q32, 9q34, 10q24, 21q21, 21q22); CeD (2p16, 6q23); AS (1p31, 2q11); IBD (1p31, 21q22); SC (3p21); PS (1p31); RA (6q23); T1D (1q32); SLE (7q32) 9
CORONARY DISEASE COR MCI (1p13, 1p32, 1q41, 2q33, 6p24, 9p21, 10q11, 19p13, 21q22); CAD (1p13, 3q22, 9p21); ICA (10q24); PD (10q24); AAA (9p21); HYP (10q24); HTG (11q23) 7
LUPUS ERYTHEMATOSUS, SYSTEMIC SLE RA (2q32, 7q32, 8p23); SS (2q32, 7q32); LN (6p21); BLC (7q32); MG (6p21); UC (7q32); CeD (6p21) 7
DIABETES MELLITUS, TYPE 1 T1D RA (2q33, 4p15, 21q22); CD (2q33, 4p15, 21q22); CeD (18p11); AA (12q13); VIT (21q22); UC (1q32) 6
HYPERTENSION HYP ICA (10q24); PD (10q24); COR (10q24); KIDNEY FAILURE, CHRONIC (16p12); CeD (12q24) 5
INFLAMMATORY BOWEL DISEASES IBD CD (1p31, 9q32, 10q22, 16q12, 20q13, 22q12); LEP (9q32); UC (1p31, 21q22); MG (22q12); AS (1p31) 5
LIVER CIRRHOSIS, BILIARY BLC RA (7q32); SLE (7q32); SS (7q32); MS (12p13); CeD (7p14) 5
CORONARY ARTERY DISEASE CAD COR (1p13, 3q22, 9p21); MCI (1p13, 9p21); AAA (9p21); T2D (2q36) 4
GLOMERULONEPHRITIS, MEMBRANOUS MG IBD (22q12); CD (22q12); SLE (6p21); CeD (6p21) 4
AORTIC ANEURYSM, ABDOMINAL AAA COR (9p21); CAD (9p21); MCI (9p21) 3
INTRACRANIAL ANEURYSM ICA PD (10q24); HYP (10q24); COR (10q24) 3
LUNG NEOPLASMS LN SLE (6p21); COPD (15q25); PVD (15q25) 3
LYMPHOMA, FOLLICULAR FL LBL (11q24); RA (6p21); LL (6p21) 3
MYOCARDIAL INFARCTION MCI COR (1p13, 1p32, 1q41, 2q33, 6p24, 9p21, 10q11, 19p13, 21q22); CAD (1p13, 9p21); AAA (9p21) 3
PARKINSON DISEASE PD HYP (10q24); COR (10q24); ICA (10q24) 3
SCLERODERMA, SYSTEMIC SS SLE (2q32, 7q32); RA (7q32); BLC (7q32) 3
SPONDYLITIS, ANKYLOSING AS UC (1p31, 2q11); IBD (1p31); CD (1p31) 3
VITILIGO VIT CeD (3q28); RA (21q22); T1D (21q22) 3
ALOPECIA AREATA AA T1D (12q13); CD (11q13) 2
CHOLANGITIS, SCLEROSING SC UC (3q21); CD (3q21) 2
DERMATITIS, ATOPIC AD GLIOMA (20q13); CD (11q13) 2
DIABETES MELLITUS, TYPE 2 T2D OBESITY (16q12); CAD (2q36) 2
HEAD AND NECK NEOPLASMS HNN GASTROINTESTINAL NEOPLASMS (10q23); ALCOHOLISM (12q24) 2
HYPERTRIGLYCERIDEMIA HTG CD (2p23); COR (11q23) 2
LEPROSY LEP CD (9q32, 13q14); IBD (9q32) 2
LEUKEMIA, LYMPHOID LL CD (2q27); FL (11q24) 2
LYMPHOMA, LARGE B-CELL, DIFFUSE LBL FL (6q21); RA (6q21) 2
MULTIPLE SCLEROSIS MS CD (10p15); BLC (12p13) 2
PERIPHERAL VASCULAR DISEASES PVD COPD (15q25); LN (15q25) 2
PROSTATIC NEOPLASMS PRN COLORECTAL NEOPLASMS (8q24); ENDOMETRIAL NEOPLASMS (17q12) 2
PSORIASIS PS UC (1p31); ARTHRITIS, PSORIATIC (6q21) 2
PULMONARY DISEASE, CHRONIC OBSTRUCTIVE COPD LN (15q25); PVD (15q25) 2

Listed are diseases that share agonistic associations with at least two traits. In the first column the considered disease is given. The second column specifies the abbreviation of the disorder in the first column. The third column contains the disease abbreviations (as defined in column two) of traits which have an agonistic link to the disorder in column one, followed by the chromosomal location of the agonistically associated variant(s) in parentheses. Here, the full MeSH term is given for traits for which no abbreviation was defined. The last column lists the count of traits agonistically linked to the disorder in column one. For the complete list of agonistically linked traits and more details see Additional file 2: Table S1.

Arnold et al.

Arnold et al. BMC Genomics 2012 13:490   doi:10.1186/1471-2164-13-490

Open Data