Additional file 1.

Figure S1. Disease-centric projection of the SVN. The SVN (see Figure 1C) is transformed in a network consisting of diseases only. Here, two traits are connected if they are associated with the same variant. The colors of the disease nodes correspond to disease classes according to the MeSH ontology, multi-colored nodes indicate an association with different disease classes. The node size reflects the number of traits a disease has shared associations with. The direction of the shared variants is indicated by the edge color reflecting the corresponding allelic information: gray indicates agonistic variant(s), red corresponds to antagonistic variant(s), and blue mark both agonistic and antagonistic signals in the two corresponding traits.

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Arnold et al. BMC Genomics 2012 13:490   doi:10.1186/1471-2164-13-490