Data prioritization and analysis workflow. We established a semi-automated curation pipeline which automatically gathers and annotates GWA data obtained from three sources (locus assignment included). Last step of the preprocessing was the manual inspection of risk alleles and odds ratios. With this data set at hand, we construct a locus-based (SLN) and a variant-based (SVN) network representation of the data. For quality reasons, we then limited analyses to the SVN and investigated the contained variants and their effects further.
Arnold et al. BMC Genomics 2012 13:490 doi:10.1186/1471-2164-13-490