Neurodegeneration and reversal stages of sall mutant embryos. (A) Schematic representation of the time points and morphological features selected to identify embryos from early stage 16 (neurodegeneration stage) and early stage 17 (neurodegeneration reversal stage). (B-E) Ultrastructural comparison of the central nervous system in WT (B, C) and homozygous (Ho) sall mutants (D, E) at embryonic stages 16 and 17. Ho16 embryos (D) show smaller cell bodies, separated by enlarged extracellular space occupied by vacuoles and other membranous material (arrows), contrasting with WT16 embryos (B, C) that present normal extracellular space. This phenotype is no longer observed a few hours later in Ho17 (E). Panels B-D are reprinted from Cantera et al. 2002.
Ferreiro et al. BMC Genomics 2012 13:483 doi:10.1186/1471-2164-13-483