Additional file 6.

Expected enrichment scores for random gene lists. We analyzed in CTen 150 lists of 100–400 randomly selected IDs for (A) mouse and (B) human Entrez Gene IDs - this resulted in a distribution of enrichment scores. The distributions were fit to a gamma distribution using the MASS package in R. Here, we show the density histogram and fitted gamma function (left hand axis) and the probability distribution function (right hand axis). The red bar highlights the enrichment score which is 95% confidently above 0 (α = 0.95 at enrichment scores of 1.66 and 1.67 in the mouse and human data, respectively).

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Shoemaker et al. BMC Genomics 2012 13:460   doi:10.1186/1471-2164-13-460