Table 4

Disease-associated chromosomal regions containing PML target genes
Chromosome region Related health conditions and references Genes in region and fold change
Symbol siP1-siC siP2-siC
ACSL3 0.59 0.44
DOCK10 0.48 0.53
C2orf33 0.47 0.58
2q37 deletion syndrome (intellectual disability, autism, short SLC16A14 0.63 0.64
2q36.3–37.1 stature, obesity, and characteristic facial features) (Casas et al. CAB39 0.42 0.58
2004) ITM2C 0.23 0.34
HTR2B 0.65 0.58
ATG16L1 0.63 0.57
MAPK13 0.55 0.50
TAPBP 0.26 0.50
NOTCH4 0.21 0.22
CFB 0.59 0.55
HSPA1B 0.66 0.48
HLA-B 0.27 0.16
leukemia, lymphoma, other cancers, multiple sclerosis, chronic HLA-C 0.59 0.45
inflammatory arthritis, type I diabetes, psoriasis, other LTB 0.65 0.65
6p21.3–22.2 autoimmue diseases. (Sawcer et al 1996, Bevan et al 2000, HCP5 0.34 0.26
Concannon et al 2005, Maleno et al 2005, Qiao et al 2007, HLA-A 0.15 0.21
Slager et al 2011, Conde et al 2010) HLA-G 0.60 0.65
PRR3 0.66 0.61
HLA-F 0.64 0.54
ZNF193 0.56 0.65
HIST1H4K 0.36 0.23
HIST1H2BD 0.45 0.44
TRIM38 0.65 0.61
TMEM106C 2.06 1.94
FKBP11 2.44 2.06
TROAP 2.50 1.55
KRT7 5.10 3.58
MFSD5 2.09 1.92
TARBP2 1.67 1.76
ATP5G2 2.11 1.53
12q13–14 Intimal sarcoma, lymphoma, gliomas. (Reifenberger et al 1994, BLOC1S1 2.12 1.95
Rao et al 1998, Bode-Lesniewska et al 2001) CDK2 4.87 3.73
FAM62A 1.65 1.69
STAT6 1.63 1.58
SHMT2 1.78 1.88
CDK4 2.02 2.29
CTDSP2 2.37 2.21
FAM119B 2.79 2.82
MSRB3 3.36 4.34
RPLP0 1.92 2.05
MLEC 2.19 1.84
Teratocarcinoma, dysmorphic features and developmental DENR 2.14 2.93
delay, beckwith-wiedemann syndrome, mitochondrial FAM101A 1.77 2.08
12q24.31–33 myopathy, asthma. (Deyo et al 1998 , Casas et al 2004, ZNF664 2.84 3.49
Brasch-Andersen et al 2006, Baple et al 2010, Al-Zahrani et al STX2 3.77 3.51
2011) POLE 3.74 2.56
PXMP2 1.79 1.67
PLAGL2 1.82 1.70
TPX2 4.68 3.11
20q11.21–23 Bladder cancer, type II diabetes,myocardial infarction. C20orf127 2.07 2.10
(Tanahashi et al 2006, Potter et al 2008, Sherva et al 2008) BLCAP 2.07 1.67
TGM2 7.82 7.35
C20orf129 4.15 2.82

Cheng and Kao

Cheng and Kao BMC Genomics 2012 13:453   doi:10.1186/1471-2164-13-453

Open Data