Table 2 |
|||
| Gene ontology (GO) and KEGG annotation for representative clusters of differentially expressed genes | |||
| Cluster | Annotation | GO term (Biological Process, level 6 or 7) or KEGG pathway name | FDR p-value |
| 1, 3 and 4 (731 genes) | GO | Positive regulation of protein metabolic process | 6.0 E-3 |
| Negative regulation of cellular macromolecule biosynthetic process | 7.3 E-3 | ||
| Triglyceride metabolic process | 1.0 E-2 | ||
| Negative regulation of gene expression | 1.0 E-2 | ||
| Proteolysis involved in cellular protein catabolic process | 1.0 E-2 | ||
| Negative regulation of kinase activity | 1.5 E-2 | ||
| Regulation of transcription, DNA-dependent | 2.1 E-2 | ||
| Protein phosphorylation | 3.3 E-2 | ||
| Antigen receptor-mediated signaling pathway | 3.3 E-2 | ||
| Regulation of phosphate metabolic process | 3.4 E-2 | ||
| Regulation of kinase activity | 3.4 E-2 | ||
| Regulation of I-kappaB kinase/NF-kappaB cascade | 3.5 E-2 | ||
| KEGG | Ubiquitin mediated proteolysis | 1.0 E-2 | |
| Sphingolipid metabolism | 1.8 E-2 | ||
| PPAR signaling pathway | 2.4 E-2 | ||
| Fatty acid metabolism | 4.6 E-2 | ||
| Peroxisome | 5.0 E-2 | ||
| 2 (557 genes) | GO | Monosaccharide catabolic process | 2.5 E-2 |
| DNA dependent DNA replication | 3.6 E-3 | ||
| Hexose metabolic process | 1.1 E-2 | ||
| Glucose metabolic process | 1.4 E-2 | ||
| Regulation of cell shape | 1.5 E-2 | ||
| DNA replication | 1.5 E-2 | ||
| Nucleoside triphosphate metabolic | 2.3 E-2 | ||
| KEGG | Glycolysis / Gluconeogenesis | 4.9 E-4 | |
| Citrate cycle (TCA cycle) | 8.9 E-4 | ||
| 6 (402 genes) | KEGG | Steroid biosynthesis | 4.4 E-3 |
| Glyoxylate and dicarboxylate metabolism | 1.2 E-2 | ||
| Pyruvate metabolism | 3.3 E-2 | ||
| 5 and 7 (250 genes) | GO | Enzyme linked receptor protein signaling pathway | 9.7 E-3 |
| Regulation of cellular protein metabolic process | 3.1 E-2 | ||
| Negative regulation of macromolecule metabolic process | 3.5 E-2 | ||
| Transmembrane receptor protein serine/threonine kinase signaling pathway | 3.6 E-2 | ||
| Negative regulation of protein metabolic process | 3.7 E-2 | ||
| Positive regulation of cellular metabolic process | 4.4 E-2 | ||
| KEGG | PPAR signaling pathway | 1.0 E-4 | |
| Glycerolipid metabolism | 1.8 E-2 | ||
| MAPK signaling pathway | 4.6 E-2 | ||
Ji et al. BMC Genomics 2012 13:441 doi:10.1186/1471-2164-13-441
