Table 2

Gene ontology (GO) and KEGG annotation for representative clusters of differentially expressed genes
Cluster Annotation GO term (Biological Process, level 6 or 7) or KEGG pathway name FDR p-value
1, 3 and 4 (731 genes) GO Positive regulation of protein metabolic process 6.0 E-3
Negative regulation of cellular macromolecule biosynthetic process 7.3 E-3
Triglyceride metabolic process 1.0 E-2
Negative regulation of gene expression 1.0 E-2
Proteolysis involved in cellular protein catabolic process 1.0 E-2
Negative regulation of kinase activity 1.5 E-2
Regulation of transcription, DNA-dependent 2.1 E-2
Protein phosphorylation 3.3 E-2
Antigen receptor-mediated signaling pathway 3.3 E-2
Regulation of phosphate metabolic process 3.4 E-2
Regulation of kinase activity 3.4 E-2
Regulation of I-kappaB kinase/NF-kappaB cascade 3.5 E-2
KEGG Ubiquitin mediated proteolysis 1.0 E-2
Sphingolipid metabolism 1.8 E-2
PPAR signaling pathway 2.4 E-2
Fatty acid metabolism 4.6 E-2
Peroxisome 5.0 E-2
2 (557 genes) GO Monosaccharide catabolic process 2.5 E-2
DNA dependent DNA replication 3.6 E-3
Hexose metabolic process 1.1 E-2
Glucose metabolic process 1.4 E-2
Regulation of cell shape 1.5 E-2
DNA replication 1.5 E-2
Nucleoside triphosphate metabolic 2.3 E-2
KEGG Glycolysis / Gluconeogenesis 4.9 E-4
Citrate cycle (TCA cycle) 8.9 E-4
6 (402 genes) KEGG Steroid biosynthesis 4.4 E-3
Glyoxylate and dicarboxylate metabolism 1.2 E-2
Pyruvate metabolism 3.3 E-2
5 and 7 (250 genes) GO Enzyme linked receptor protein signaling pathway 9.7 E-3
Regulation of cellular protein metabolic process 3.1 E-2
Negative regulation of macromolecule metabolic process 3.5 E-2
Transmembrane receptor protein serine/threonine kinase signaling pathway 3.6 E-2
Negative regulation of protein metabolic process 3.7 E-2
Positive regulation of cellular metabolic process 4.4 E-2
KEGG PPAR signaling pathway 1.0 E-4
Glycerolipid metabolism 1.8 E-2
MAPK signaling pathway 4.6 E-2

Ji et al.

Ji et al. BMC Genomics 2012 13:441   doi:10.1186/1471-2164-13-441

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