Additional file 2.

Table S2. Mutations in coding regions detected by Winter Genomics Inc. This table lists the data provided by Winter Genomics Inc. (WG) obtained for the whole genome sequence of the PB12 strain in comparison to the parental strains JM101 and PB11. Importantly, PB11 strain was sequenced by WG and the same nucleotide sequences as in the parental strain JM101 were determined (data not shown). Therefore all the point mutations detected in PB12 by RN and WG appeared during the laboratory evolution process. Section A includes a list of 27 genes (21+6) in which, accordingly to this company non-synonymous point mutations occurred changing the coding regions in structural genes. 21 of these genes were also detected by RN (Table 1A). The table also includes (Section B) the list of 18 genes in which synonymous mutations also occurred, accordingly to WG. Those 16 in common with RN are in bold letters.

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Aguilar et al. BMC Genomics 2012 13:385   doi:10.1186/1471-2164-13-385