Additional file 8.
Figure S6. Fungal toxin biosynthesis. Fungi produce toxins to destroy host cellular functions. They can be non-host specific or host specific. Fungi have many genes to control the biosynthesis, export, and regulation of the toxins. Cercosporin is a non-host specific toxin. A polyketide synthase gene, CTB1, plays a key role in cercosporin biosynthesis. CFP encodes a cercosporin Transporter exporting cercosporin, CZK3, which regulates cercosporin biosynthesis. Comparing to the non-host specific toxins, some toxins are active only toward hosts, i.e. host specific toxins, such as HC-toxin, AK-toxin, AM-toxin, and ACT-toxin. HTS1 encodes a multifunctional cyclic peptide synthetase involved in the biosynthesis of HC-toxin. Besides HTS1, ToxC and ToxF are also essential for toxin biosynthesis and pathogenicity. AKT1, which encodes a series of carboxyl-activating enzymes, and AKT2 are involved in the biosynthesis of the AK-toxin. The AMT gene is essential for the biosynthesis of the AM-toxin. ACTTS2 and ACTTS3 are essential genes for ACT-toxin biosynthesis.
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Zhu et al. BMC Genomics 2012 13:382 doi:10.1186/1471-2164-13-382