Table 1

Comparison of the differentially expressed genes in theS. mansoni-infected and the TNBS-treated ileum with candidate genes located within IBD susceptibility loci
Gene symbol IBD type S. mansoni-infected ileum TNBS-treated ileum
NOD2 CD ND ND
ATG16 CD ND ND
IRGM CD ND
LRRK2 CD ND ND
PTPN22 CD ND ND
CCR6 CD ND
IL-2RA CD ND ND
IL-18RAP CD ND ND
IL-27 CD ND ND
ERAP2 (Erap1/Eraap) CD ND ND
ITLN1 CD ND ND
CCL2 (Ccl12) CD ND ND
CCL7 CD ND ND
TNFSF11 CD ND ND
BACH2 CD ND ND
TAGAP CD ND ND
VAMP3 CD ND ND
DENNDIB CD ND ND
DNMT3A CD ND ND
GCKR CD ND ND
THADA CD ND ND
SP140 CD ND ND
PRDX5 CD ND ND
ZFP36L1 CD ND ND
ZMIZ1 CD ND ND
MUC1 CD ND ND
SCAMP3 CD ND ND
CPEB4 CD ND ND
FADS1 CD ND ND
SLC22A5 CD ND ND
ECM1 UC ND ND
HNF4A UC ND ND
CDH1 UC ND ND
LAMB1 UC ND ND
GNA12 UC ND ND
IFNG UC ND ND
IL-26 (Il-22) UC ND ND
IL-8RA/IL-8RB UC ND
IL-2 UC ND ND
IL-21 UC ND ND
IL-7R UC ND ND
TNFRSF9 UC ND ND
TNFRSF14 UC ND
FCGR2A (Fcgr3/Fcgr2b) UC ND ND
IRF5 UC ND ND
LSP1 UC ND ND
OTUD3 UC ND ND
PLA2G2E UC ND ND
DAP UC ND ND
PIM3 UC ND ND
CAPN10 UC ND ND
IL-23R CD/UC ND ND
IL-12B CD/UC ND ND
STAT3 CD/UC ND
AK2 CD/UC ND ND
TYK2 CD/UC ND ND
NKX2-3 CD/UC ND ND
CREM CD/UC ND ND
C11Orf30 (2210018M11Rik) CD/UC ND ND
ORMDL3 CD/UC ND ND
RTEL1 CD/UC ND ND
PTGER4 CD/UC ND
KIF21B CD/UC ND ND
CDKAL1 CD/UC ND ND
ZNF365 (Zfp365) CD/UC ND ND
HLA-DRB1 (H2-Eb1) CD/UC ND
MST1 CD/UC ND ND
IL-10 CD/UC ND
CARD9 CD/UC ND ND
REL CD/UC ND ND
PRDM1 CD/UC ND ND
TNFSF15 CD/UC ND ND
ICOSLG (Icosl) CD/UC ND ND
IL-1R2 CD/UC ND
YDJC (1810015A11Rik, Ccdc116) CD/UC ND ND
SMAD3 CD/UC ND ND
PTPN2 CD/UC ND ND

The table compares candidate genes within IBD susceptibility loci to the differentially expressed genes in the S. mansoni-infected and in the TNBS-treated ileum. Gene symbol denotes the gene symbol in human along with the murine homologue where applicable in brackets. CD, human Crohn's disease; UC, human ulcerative colitis; ND, no difference; ↑, upregulated; ↓, downregulated. No genes were overlapping in the S. mansoni-infected ileum, while 9 genes were overlapping in the TNBS-treated ileum.

Avula et al.

Avula et al. BMC Genomics 2012 13:377   doi:10.1186/1471-2164-13-377

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