Overlap between miRNAs exported by different cell types. All miRNAs identified in HEK293T cells were coloured according to their EV:cells ratio with most preferentially exported red and most retained within the cell green. The 100 miRNAs with the smallest and largest log2(EV/cell) values are shown on the left. Publicly available data sets for various cell types were analysed in a similar fashion and compared with our data. The pattern of exported and retained miRNAs shows similarities between the different data sets. The most exported miRNAs cluster predominantly in the upper part of the graph which is enlarged in the central panel to show the identities of the consistently exported miRNAs. The right-hand column (column K) illustrates the miRNAs ranked according to reduction in Ago2 knockout tissue relative to wildtype reported by Yang et al.. Arrows indicate miRNAs with high ranks in both Ago2 and other data sets. Blank white spaces indicate that a miRNA was either not detected or not assayed.
Guduric-Fuchs et al. BMC Genomics 2012 13:357 doi:10.1186/1471-2164-13-357