MiRNA expression in cells and EVs. Scatter plots of the miRNA expression levels in cells and EVs of non-transfected and pSM30-miR-146a transfected cells. A) There was extremely high correlation between miRNA expression values in non-transfected and transfected cells (R2 = 0.9). B) Strong correlation was also observed between EVs from non-transfected and transfected cells (R2 = 0.8). C) Correlation between transfected and non-transfected cells and D) between EVs from transfected and non-transfected cells was much lower (R2 = 0.6). For pSM30-miR-146a transfected cells and EVs expression levels were renormalized to RPMM following exclusion of miR-146a reads.
Guduric-Fuchs et al. BMC Genomics 2012 13:357 doi:10.1186/1471-2164-13-357