Figure 5.

Gene expression in response to H2O2exposure in the Δura3parent vs ΔVNG0258Hmutant strains. Each line in each graph represents the mean expression profile of gene clusters that rely on VNG0258H for their appropriate expression (A-G) or those that respond to 25 mM H2O2 treatment regardless of strain background (H and J). Time points before and after H2O2 exposure in the Δura3 parent strain (black) or ΔVNG0258H mutant (red) are divided by the dotted line. (A) Genes requiring VNG0258H for repression regardless of condition. (B) Genes requiring VNG0258H for activation regardless of condition. (C) Genes requiring VNG0258H for repression in the presence of H2O2. (D) Genes requiring VNG0258H for activation in the presence of H2O2. Dotted traces represent late waves of gene expression. (E) Genes requiring VNG0258H for repression in the absence of H2O2. (F) Genes requiring VNG0258H for impulse-like dynamic induction. (G) Genes requiring VNG0258H for impulse-like dynamic repression. (H) Genes induced in response to H2O2 but independent of VNG0258H (note the difference in y-axis scale between F and H). (J) Genes repressed in response to H2O2 but independent of VNG0258H. Gene expression profiles for individual genes in each cluster are shown in heat maps in Additional file 8: Figure S3. Detailed annotations for genes in each cluster are listed in Additional file 4: Table S2.

Sharma et al. BMC Genomics 2012 13:351   doi:10.1186/1471-2164-13-351
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