Homology of VNG0258H winged helix-turn-helix (wHTH) putative transcription factor with haloarchaeal homologs and bacterial matches to wHTH domain. Residues in bold blue font depict those known to interact with the major groove of OhrR in B. subtilis, whereas those in bold red letters represent residues of the wing that contact the minor groove . In the N- or C-terminal domains (white overbar), no homology was detected outside the halophilic archaea. Perfectly conserved residues are shaded black, whereas conservatively substituted residues are shaded grey. Black overbars designate characterized helix-turn-helix (HTH) and wing regions from bacterial MarR family members. Hvo_0730, Haloferax volcanii (GenBank genome accession NC002945); Hwa, Haloquadratum walsbyi (NC_008212); Htu, Haloterrigena turkmenica (NC_013743); Nmag, Natrialba magadii (NC_013922); Huta, Halorhabdus utahensis (NC_013158); HacjB3, Halalkalicoccus jeotagali.B3 (NC_014297); Hsal, Halobacterium salinarum NRC-1 (NC_002607); Hma, Haloarcula marismortui (NC_006396); Bsu, Bacillus subtilis; Eco, E. coli. Numbers following each species name refer to gene unique identifiers in each genome. OE1405R in H. salinarum is a cross-reference to the corresponding gene in the R1 strain .
Sharma et al. BMC Genomics 2012 13:351 doi:10.1186/1471-2164-13-351