Table 1

List of 31 genes selected as a radiosensitivity signature from four microarray platforms
Symbol Description Location Expression in radiosensitive cell
ACTN1 actinin, alpha 1 Cytoplasm Down (0.42)
ANXA2 annexin A2 Plasma Membrane Down (0.36)
ANXA5 annexin A5 Plasma Membrane Down (0.42)
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta Cytoplasm Up (−0.49)
CAPNS1 calpain, small subunit 1 Cytoplasm Down (0.48)
CBR1 carbonyl reductase 1 Cytoplasm Down (0.41)
CCND1 cyclin D1 Nucleus Down (0.54)
CD63 CD63 molecule Plasma Membrane Down (0.51)
CORO1A coronin, actin binding protein, 1A Cytoplasm Up (−0.46)
CXCR4 chemokine (C-X-C motif) receptor 4 Plasma Membrane Up (−0.46)
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) Plasma Membrane Down (0.60)
EMP2 epithelial membrane protein 2 Plasma Membrane Down (0.41)
HCLS1 hematopoietic cell-specific Lyn substrate 1 Nucleus Up (−0.58)
HTRA1 HtrA serine peptidase 1 Extracellular Space Down (0.52)
ITGB5 integrin, beta 5 Plasma Membrane Down (0.47)
LAPTM5 lysosomal protein transmembrane 5 Plasma Membrane Up (−0.50)
LRMP lymphoid-restricted membrane protein Cytoplasm Up (−0.49)
MYB v-myb myeloblastosis viral oncogene homolog (avian) Nucleus Up (−0.59)
PFN2 profilin 2 Cytoplasm Down (0.61)
PIR pirin (iron-binding nuclear protein) Nucleus Down (0.43)
PKM2 pyruvate kinase, muscle Cytoplasm Down (0.44)
PTMS parathymosin Nucleus Down (0.48)
PTPRC protein tyrosine phosphatase, receptor type, C Plasma Membrane Up (−0.55)
PTPRCAP protein tyrosine phosphatase, receptor type, C-associated protein Plasma Membrane Up (−0.49)
PYGB phosphorylase, glycogen; brain unknown Down (0.35)
RAB13 RAB13, member RAS oncogene family Plasma Membrane Down (0.43)
RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein)
Cytoplasm Down (0.47)
SCRN1 secernin 1 Cytoplasm Down (0.40)
SQSTM1 sequestosome 1 Cytoplasm Down (0.48)
TWF1 twinfilin, actin-binding protein, homolog 1 (Drosophila) Cytoplasm Down (0.43)
WAS Wiskott-Aldrich syndrome (eczema-thrombocytopenia) Cytoplasm Up (−0.60)

“Down” refers to decreased expression observed in radiosensitive cells relative to radioresistant cells, determined as the slope of the correlation coefficient. “Up” refers to increased expression in radiosensitive cells.

Kim et al.

Kim et al. BMC Genomics 2012 13:348   doi:10.1186/1471-2164-13-348

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