Open Access Research article

Microbial transformation from normal oral microbiota to acute endodontic infections

William W L Hsiao1, Kevin L Li2, Zhenqiu Liu3, Cheron Jones1, Claire M Fraser-Liggett1 and Ashraf F Fouad2*

Author Affiliations

1 University of Maryland School of Medicine, Institute for Genome Sciences, Baltimore, MD, 20201, USA

2 University of Maryland School of Dentistry, Department of Endodontics, Prosthodontics and Operative Dentistry, Baltimore, MD, 20201, USA

3 University of Maryland School of Medicine, Department of Epidemiology and Preventive Medicine, Baltimore, MD, 20201, USA

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BMC Genomics 2012, 13:345  doi:10.1186/1471-2164-13-345

Published: 28 July 2012

Additional files

Additional file 1:

Bar graph showing the number of reads from each sample.

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Additional file 2:

Rarefaction curves by sample sites for each subject.

Format: XLSX Size: 274KB Download file

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Additional file 3:

Relative abundance (before_arcsine) and transformed abundance (after_arcsine) of all genera found in each of the samples.

Format: XLSX Size: 65KB Download file

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Additional file 4:

Differentially distributed genera (p<0.05 are listed, p<0.01 are highlighted) detected using ANOVA and paired-t tests of the transformed abundance data. The original counts for each genus are listed to show that most of these organisms are not dominant organisms in the samples.

Format: XLSX Size: 56KB Download file

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Additional file 5:

SpeciateIT results.

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Additional file 6:

Differentially distributed OTUs (1% cutoff) annotated with Mothur k-mer Classifier and BLAST searches against HOMD and NCBI databases.

Format: XLSX Size: 415KB Download file

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Additional file 7:

Paired-t tests and ANOVA tests of systemic infection samples vs. localized infection samples.

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Additional file 8:

Table S2. Barcoded PCR primers used for the amplification of 16S rRNA genes.

Format: XLSX Size: 43KB Download file

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