Figure 1.

Schematic representation of the S. hygroscopicus 5008 chromosome and two plasmids. (A) The chromosome atlas. The outer scale is numbered in megabases from the left to the right ends and indicates the core (red) and noncore (blue) chromosomal regions; Circle 1 and 2 (forward and reverse strands), predicted protein coding sequences colored according to COG function categories; Circle 3 and 4 (forward and reverse strands), distribution of conserved (red) or strain-specific genes (blue) in 5008 compared with other Streptomyces chromosomes; Circle 5, distribution of secondary metabolic gene clusters (red); Circle 6, distribution of tRNA (red) and rRNA operon (blue); Circle 7, GC content; Circle 8, GC bias. Ori, origin of replication. val, validamycin biosynthetic gene cluster. (B) Atlas of linear plasmid pSHJG1. Circle 1 and 2, predicted coding sequences on the plus and minus strands, respectively, colored according to COG functional categories; Circle 3, GC content; Circle 4, GC bias. (C) Atlas of circular plasmid pSHJG2. Circle 1 and 2, predicted coding sequences on the plus and minus strands, respectively, colored according to COG functional categories; Circle 3, GC content; Circle 4, GC bias.