Table 2
Top 25 GO categories overrepresented in SI of SPF mice compared to GF mice
GOID Term Number of Probes p_int
GO:0015992 proton transport 67 < 1.0E-18
GO:0015986 ATP synthesis coupled proton transport 44 < 1.0E-18
GO:0006099 tricarboxylic acid cycle 39 < 1.0E-18
GO:0016192 vesicle-mediated transport 95 < 1.0E-18
GO:0006631 fatty acid metabolic process 63 < 1.0E-18
GO:0045454 cell redox homeostasis 46 1.11E-16
GO:0006754 ATP biosynthetic process 40 2.78E-15
GO:0006096 Glycolysis 56 5.32E-13
GO:0016481 negative regulation of transcription 68 1.05E-12
GO:0042254 ribosome biogenesis and assembly 96 2.27E-11
GO:0009987 cellular process 85 2.41E-11
GO:0001501 skeletal development 27 3.77E-11
GO:0006461 protein complex assembly 52 3.84E-11
GO:0021799 cerebral cortex radially oriented migration 5 5.23E-11
GO:0021813 cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial cell migration 5 5.23E-11
GO:0021589 cerebellum structural organization 5 5.23E-11
GO:0021942 radial glia guided migration of Purkinje cell 5 5.23E-11
GO:0000160 two-component signal transduction system (phosphorelay) 31 6.78E-11
GO:0008654 phospholipid biosynthetic process 41 1.00E-10
GO:0007031 peroxisome organization and biogenesis 20 4.44E-10
GO:0007399 nervous system development 96 7.76E-10
GO:0044267 cellular protein metabolic process 26 1.06E-09
GO:0006396 RNA processing 75 1.15E-09
GO:0007162 negative regulation of cell adhesion 11 2.04E-09
GO:0007266 Rho protein signal transduction 38 2.27E-09
GO:0007229 integrin-mediated signaling pathway 36 8.14E-05

MGP analysis was performed on GO BP categories which contains 4 ~ 99 genes (“Number of Probes”). The categories were sorted according to the integrated p value (p_int) and top 25 are represented. The categories related to energy cycle are noted (e.g., “proton transport”, “tricarboxylic acid cycle”, “ATP biosynthetic process”, and “Glycolysis”).

Yamamoto et al. BMC Genomics 2012 13:335   doi:10.1186/1471-2164-13-335

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