Principal components analysis (PCA) of the GC-TOFMS data. The rotation matrix that connects the 162 identified metabolites with the principal components (PCs) was determined using the TS data. In the TS, the 1st PC captured 34.9% of the total variance; in the VS the 1st PC captured 34.6% of the total variance. The 1st PC was significantly decreased in cancer compared to normal tissues in TS (p = 2.2E-22) and VS (p = 8.4E-41).
Budczies et al. BMC Genomics 2012 13:334 doi:10.1186/1471-2164-13-334