Table 5

Summary of predicted RAS-related miRNA targets
miRNA RAS + Tumors RAS- Tumors Target Scan Predictions miRanda Predictions
hsa-miR-200b On Off DROSHA
hsa-miR-27b On Off EIF2C2, DROSHA EIF2C2, DROSHA
hsa-miR-424 On Off DICER1, TARBP2 EIF2C2, TARBP2
hsa-miR-99a On Off EIF2C2 EIF2C2
hsa-miR-200c On Off DROSHA
hsa-miR-31 On Off DICER1, DGCR8 DICER1, DGCR8
hsa-miR-15a On Off DICER1, TARBP2 EIF2C2, DICER1, TARBP2
hsa-miR-16 On Off DICER1, TARBP2 EIF2C2, DICER1, TARBP2
hsa-miR-27a On Off EIF2C2, DROSHA EIF2C2, DROSHA

Predicted mRNA targets of "RAS-switching" miRNAs related to miRNA processing are summarized. The columns denoted "RAS + Tumors" and "RAS- Tumors" indicate whether RAS-switching miRNAs are activated (On) or inactivated (Off) relative to normal tissue for RAS-active and RAS-inactive tumors respectively.

Fountzilas et al.

Fountzilas et al. BMC Genomics 2012 13:332   doi:10.1186/1471-2164-13-332

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