Table 1 |
||||||
| Related genes with brain expression patterns associated with domestication in multiple species | ||||||
| Genes | Zebrafish Strain | Zebrafish Domestication | Rainbow Trout Domestication[[37]] | Fox Tameness[[35]] | Dog-Wolf Comparison[[36]] | Mouse Behavior[[47]] |
| Caspase | casp2, casp3a, caspb | casp3a (+) | casp8 (+) | |||
| Coiled-coil domain containing | ccdc47, ccdc53, ccdc93, Dr.18793.1.A1_at | Dr.18793.1.A1_at (+) | BU965755 (+) | |||
| Collagens | col1a2, col2a1a, col5a2l, col9a2, wu:fa99c11, zgc:56518 | col1a1 (+), col1a2 (+) | col1a1a, col3a1b | |||
| Cytochrome c oxidase | cox2 (–), cox3 (–) | cox5ab | ||||
| DNAj | dnajc12 | dnajc3 (–) | dnajc6(AI840916)c | |||
| Eukaryotic translation initiation factors | eif1ax, eif4enif1 | eif1ax (+), eif4enif1 (–) | eif3s2 (+), eif3s7 (+) | |||
| Glutathione peroxidases | gpx1a, gpx4a | gpx3 (–) | gpx3d | |||
| Hemoglobins | hbaa1, ba1 | hba,hba1, hba4, hbb, hbb1, hbb2, hbb4 (all +) | hbe, hbg1, hbg2, hba, hbz (all –) | hbaa1e | ||
| NADH dehydrogenase (ubiquinone) | ndf1a4 (+) | ndufb8 (–) | ||||
| Neurofilament, light peptide | CB514125 (+) | nefle | ||||
| Potassium channel proteins | Dr.16785.1.A1_at (kcnk1) | kcnj4 (–) | AI835316 (kcnc2)a | |||
| Purkinje cell protein 4 | pcp4 (*) | pcp4 (+) | ||||
| Selenoprotein P | sepp1a | sepp1a (+) | sepp1 (+) | |||
| Syntaxins | stx3a, stx6, syntaxin1b | stx1b2 (+) | ||||
| Syntaxin binding proteins | stxbp3 (+) | stxbp2b, stxbp6e | ||||
| Transthyretin (prealbumin, amyloidosis type I) | ttr (*) | ttr (+) | ||||
Studies included the present study on zebrafish (Danio rerio), an analysis of domestication in rainbow trout (Oncorhynchus mykiss) [37], silver fox (Vulpes vulpes) selected for tameness [35], a comparison between dog (Canis familiaris) and wolf (Canius lupus) [36], and an analysis of strain variation in laboratory mice (Mus musculus) [47]. Positive signs (+) indicated up-regulation in domesticated populations relative to wild, while negative signs (–) indicate down-regulation. An asterisk (*) indicates that the direction of differential expression differed among brain regions.
a Negative correlation with open field activity; b Positive correlation with distance traveled after ethanol administration; c Positive correlation with electroconvulsive threshold; d Negative correlation with electroconvulsive threshold; e Positive correlation with open field activity.
Drew et al. BMC Genomics 2012 13:323 doi:10.1186/1471-2164-13-323
