Table 1

Related genes with brain expression patterns associated with domestication in multiple species
Genes Zebrafish Strain Zebrafish Domestication Rainbow Trout Domestication[[37]] Fox Tameness[[35]] Dog-Wolf Comparison[[36]] Mouse Behavior[[47]]
Caspase casp2, casp3a, caspb casp3a (+) casp8 (+)
Coiled-coil domain containing ccdc47, ccdc53, ccdc93, Dr.18793.1.A1_at Dr.18793.1.A1_at (+) BU965755 (+)
Collagens col1a2, col2a1a, col5a2l, col9a2, wu:fa99c11, zgc:56518 col1a1 (+), col1a2 (+) col1a1a, col3a1b
Cytochrome c oxidase cox2 (–), cox3 (–) cox5ab
DNAj dnajc12 dnajc3 (–) dnajc6(AI840916)c
Eukaryotic translation initiation factors eif1ax, eif4enif1 eif1ax (+), eif4enif1 (–) eif3s2 (+), eif3s7 (+)
Glutathione peroxidases gpx1a, gpx4a gpx3 (–) gpx3d
Hemoglobins hbaa1, ba1 hba,hba1, hba4, hbb, hbb1, hbb2, hbb4 (all +) hbe, hbg1, hbg2, hba, hbz (all –) hbaa1e
NADH dehydrogenase (ubiquinone) ndf1a4 (+) ndufb8 (–)
Neurofilament, light peptide CB514125 (+) nefle
Potassium channel proteins Dr.16785.1.A1_at (kcnk1) kcnj4 (–) AI835316 (kcnc2)a
Purkinje cell protein 4 pcp4 (*) pcp4 (+)
Selenoprotein P sepp1a sepp1a (+) sepp1 (+)
Syntaxins stx3a, stx6, syntaxin1b stx1b2 (+)
Syntaxin binding proteins stxbp3 (+) stxbp2b, stxbp6e
Transthyretin (prealbumin, amyloidosis type I) ttr (*) ttr (+)

Studies included the present study on zebrafish (Danio rerio), an analysis of domestication in rainbow trout (Oncorhynchus mykiss) [37], silver fox (Vulpes vulpes) selected for tameness [35], a comparison between dog (Canis familiaris) and wolf (Canius lupus) [36], and an analysis of strain variation in laboratory mice (Mus musculus) [47]. Positive signs (+) indicated up-regulation in domesticated populations relative to wild, while negative signs (–) indicate down-regulation. An asterisk (*) indicates that the direction of differential expression differed among brain regions.

a Negative correlation with open field activity; b Positive correlation with distance traveled after ethanol administration; c Positive correlation with electroconvulsive threshold; d Negative correlation with electroconvulsive threshold; e Positive correlation with open field activity.

Drew et al.

Drew et al. BMC Genomics 2012 13:323   doi:10.1186/1471-2164-13-323

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