Table 7

Expression profiles of miRNAs associated with metabolic disorder risk factors
miRNA Low LDL-C (Chow vs HCHF) p value High LDL-C (Chow vs HCHF) p value Biological processes associated with disease risk factors References
miR-29b Down 0.018 Down 0.01 Demethylation of MMP-2/MMP-9 genes involved in cell migration in aorta [43]
miR-26a-1* Down 0.007 Down 0.32 Regulator of vascular smooth muscle cell function [44]
miR-221 Down 0.45 Down 0.02 Angiogenesis in hypertrophy [41]
miR-222 Down 0.39 Down 0.01 Angiogenesis in hypertrophy [41]
miR-222* Up 0.98 Down 0.66
miR-143 Down 0.67 Down 0.17 Proliferation of vascular smooth muscle cells [45]
miR-122 Up 0.69 Down 0.19 Lipid metabolism [30,32]
miR-122* Down 0.43 Down 0.38
miR-335 Up 0.48 - - Lipid metabolism [31]
miR-335* Down 0.31 Down 0.29
miR-21 Down 0.63 Down 0.62 Cell proliferation in carotid artery [46]
miR-1 Down 0.42 Down 0.35 Repolarization and diastolic activity [47]
miR-146a,b Down 0.12 Down 0.36 LDL-C oxidization accumulation in monocytes [23][24]
miR-155 Down 0.17 Down 0.43 Oxidized LDL-C accumulation in monocytes [24]
miR-130b Down 0.98 Down 0.59 Arteriosclerosis obliterans [48]
miR10a Down 0.39 Down 0.47 Regulation of pro-inflammation in aorta [49]

- Indicates that the miRNA was not detected. miRNA stars (*) are presented for comparison with mature miRNAs.

Karere et al.

Karere et al. BMC Genomics 2012 13:320   doi:10.1186/1471-2164-13-320

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